Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's -demethylation via CYP2D6

Anette Green Nielsen (1) , Rasmus Steen Pedersen (1) , Lene Noehr-Jensen (1) , Per Damkier (2) , Kim Brosen (1)

1 Institute of Public Health, Clinical Pharmacology
2 Department of Biochemistry, Pharmacology & Genetics

Mots clés: Paroxetine; Tramadol; Interaction; CYP2D6; Pupillometry; Metabolic ratios

Anette Green Nielsen, Rasmus Steen Pedersen, Lene Noehr-Jensen, Per Damkier, Kim Brosen. Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's -demethylation via CYP2D6. European Journal of Clinical Pharmacology, 2010, 66 (7), pp.655-660. ⟨10.1007/s00228-010-0803-8⟩. ⟨hal-00581541⟩