Classical swine fever: comparison of oronasal immunisation with CP7E2alf marker and C-strain vaccines in domestic pigs

Marylène Tignon , Gábor Kulcsár , Andy Haegeman , Timea Barna , Katalin Fábián , Réka Lévai , Yves van Der Stede , Attila Farsang , Robert Vrancken , Katinka Belák , Frank Koenen

Effective oronasal vaccination against classical swine fever (CSF) is essential to achieve protection in wild boar. However the currently available live CSF vaccines, e.g. C-strain, do not allow serological differentiation between infected and vaccinated animals (DIVA). A modified live marker vaccine candidate (CP7E2alf) has been recently developed (Reimann et al., 2004). Here we report on the comparison of CP7E2alf and C-strain virus vaccines during 98 days following oronasal immunisation in domestic pigs.

Mots clés: Classical swine fever virus (CSFV); DIVA marker vaccine; CP7E2alf; C-strain; Oronasal vaccination; Diagnostic tests

Marylène Tignon, Gábor Kulcsár, Andy Haegeman, Timea Barna, Katalin Fábián, et al.. Classical swine fever: comparison of oronasal immunisation with CP7E2alf marker and C-strain vaccines in domestic pigs. Veterinary Microbiology, 2010, 142 (1-2), pp.59. ⟨10.1016/j.vetmic.2009.09.044⟩. ⟨hal-00578401⟩