Corneal Collagen Crosslinking in post-LASIK keratectasia

Josefina P. Salgado (1) , Ramin Khoramnia (1) , Chris P. Lohmann (1) , Christoph Winkler von Mohrenfels (1)

1 Augenklinik rechts der Isar, Technische Universität München

Abstract: Background/Aims: To evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for post-laser in situ keratomileusis (LASIK) keratectasia. Methods: Crosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardized protocol (UCVA, BCVA, slit-lamp examination, pachymetry and topography), was performed preoperatively, 1, 3, 6 and 12 months after crosslinking. Results: The mean BCVA was 0.19 (SD ±0.21) logMAR preoperatively, 0.25 (SD ±0.17) 1 month, 0.20 (SD ±0.20) 3 months, 0.18 (SD ±0.21) 6 months and 0.15 (SD ±0.14) 12 months postoperatively (statistically significant postop1-postop6, p=0.0335). The maximum k-readings were 44.12 (SD ±3.97) preoperatively, 46.23 (SD ±4.14) 1 month, 43.88 (SD ±4.25) 3 months, 45.06 (SD ±5.07) 6 months and 44.43 (SD ±4.06) 12 months postoperatively (statistically significant preop -postop1, p=0.0281). Conclusion: Crosslinking in patients with iatrogenic keratectasia stabilized the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilize the refraction and the corneal topography, hence to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty.

Mots clés: Cornea

Josefina P. Salgado, Ramin Khoramnia, Chris P. Lohmann, Christoph Winkler von Mohrenfels. Corneal Collagen Crosslinking in post-LASIK keratectasia. British Journal of Ophthalmology, 2010, 95 (4), pp.493. ⟨10.1136/bjo.2010.179424⟩. ⟨hal-00577965⟩