Migration of Bisphenol A from polycarbonate baby bottles under real use conditions

Niki C. Maragou (1) , Athina Makri (1) , Eugenia N. Lampi (2) , Nikolaos S. Thomaidis (3) , Michael A Koupparis (1)

1 Department of Chemistry
2 Laboratory of Materials in Contact with Food
3 Department of Chemistry

Migration of the potential endocrine disrupter bisphenol A (BPA) from 31 polycarbonate (PC) baby bottles in aqueous food simulants was studied under real repetitive use, with a sensitive and fully validated liquid chromatographic method with fluorescence detection. Confirmation of BPA presence was performed by liquid chromatography-mass spectrometry (LC-MS). The effects of cleaning with dishwasher or brush, the sterilization in boiling water and the temperature of migration were examined. It was shown that temperature was the crucial factor for the migration of BPA from the plastic bottles to water. All the samples released BPA at a concentration range of 2.4-14.3 ìg kg-1, when they were filled with boiled water and left at ambient temperature for 45 min. The decrease of BPA release in the sterilization water and in food simulant over twelve cycles of use indicated that the hypothesis of polymer degradation in water is rather doubtful. The estimated infantile dietary exposure, regarding the use of PC baby bottles, ranged between 0.2 and 2.2 ìg kg-1 bw d-1, which is below the Tolerable Daily Intake of 50 ìg kg-1 bw, recently established by EFSA.

Mots clés: Life Sciences

Niki C. Maragou, Athina Makri, Eugenia N. Lampi, Nikolaos S. Thomaidis, Michael A Koupparis. Migration of Bisphenol A from polycarbonate baby bottles under real use conditions. Food Additives and Contaminants, 2008, 25 (03), pp.373-383. ⟨10.1080/02652030701509998⟩. ⟨hal-00577472⟩