Acute lower limb ischemia due to thrombo-embolic arterial occlusions in two previously healthy men with markedly elevated Lp(a)

Gabriella V Bedarida (1) , Ulrich Hoffmann , Federico Tatò (1)

1 Division of Vascular Medicine

Lipoprotein (a) (Lp(a)) is a well-documented risk factor for atherosclerotic cardiovascular disease. Its role in acute thrombo-embolic occlusions of peripheral arteries is not known. We describe two cases of multiple, acute, peripheral arterial occlusions in two previously healthy men with markedly elevated Lp(a). Both cases had unsatisfactory results after percutaneous and surgical revascularization procedures. Experience yielded in these two cases suggests that when an unfavorable out-come occurs in a peripheral artery disease patient in the absence of the regular risk factors, Lp(a) should be determined and its role investigated.

Mots clés: acute limb ischemia; arterial thrombosis; Lp(a); myointimal hyperplasia; peripheral artery disease

Gabriella V Bedarida, Ulrich Hoffmann, Federico Tatò. Acute lower limb ischemia due to thrombo-embolic arterial occlusions in two previously healthy men with markedly elevated Lp(a). Vascular Medicine, 2006, 11 (4), pp.259-262. ⟨10.1177/1358863x06072218⟩. ⟨hal-00571392⟩