Risk Factors for Idiopathic Orbital Inflammation: A Case-control Study

Ward Rogier Bijlsma (1) , Carla van Gils (1) , Dion Paridaens (2) , Maarten P Mourits (3) , Rachel Kalmann (1)

1 University Medical Center [Utrecht]
2 Rotterdam Eye Hospital
3 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]

Objective: To identify risk factors involved in the development of idiopathic orbital inflammation (IOI). Methods: Case-control study of 69 adults who had had a first episode of IOI and 296 adult controls with rhegmatogenous retinal detachment (RD) selected from 3 orbital centers in the Netherlands between 2000 and 2006. Participants filled out a questionnaire on demographic factors, medical history, health status, and exposures for the 2 years prior to disease presentation. In addition, women were questioned about previous or current pregnancies and their hormonal status. Odds ratios (ORs) and accompanying 95% confidence intervals (CIs) for IOI in relation to potential risk factors such as body mass index (BMI), bisphosphonates, and autoimmune disease were estimated. ORs were adjusted for age, sex, socioeconomic status, smoking, and blunt orbital trauma using logistic regression. Analyses were carried out both with and without multiple imputation of missing values. Results: The risk of IOI was increased in participants who had a higher BMI (third vs first tertile: OR, 2.88; 95% CI, 1.32-6.32) and in participants who used bisphophonates (OR, 8.68; 95% CI, 1.16-65.0). The risk was decreased in participants with a higher socioeconomic status (third vs first tertile: OR, 0.38; 95% CI, 0.17-0.84) and in women who were older at first childbirth (third vs first tertile: OR, 0.14; 95% CI, 0.03-0.64). A close to significant association was found for IOI and autoimmune disease (OR, 2.56; 95% CI, 0.93-7.05). Conclusions: IOI is associated with lower socioeconomic status, higher BMI, and use of oral bisphosphonates. In women, IOI is also associated with younger age at first childbirth.

Mots clés: Orbit; Inflammation; Epidemiology

Ward Rogier Bijlsma, Carla van Gils, Dion Paridaens, Maarten P Mourits, Rachel Kalmann. Risk Factors for Idiopathic Orbital Inflammation: A Case-control Study. British Journal of Ophthalmology, 2010, 95 (3), pp.360. ⟨10.1136/bjo.2009.175190⟩. ⟨hal-00567047⟩