Influence of water-soluble flavonoids: Quercetin5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt on antioxidant parameters in the subacute cadmium intoxication mouse model

Ewa Chlebda , Jan Magdalan , Anna Merwid-Ląd , Małgorzata Trocha , Maria Kopacz , Anna Kuźniar , Dorota Nowak , Adam Szeląg

Water-soluble quercetin5'-sulfonic acid sodium salt (NaQSA) and morin-5'-sulfonic acid sodium salt (NaMSA) could exert an antagonistic effect on cadmium intoxication. The aim of the study was to examine the influence of these substances on superoxide dismutase (SOD) and glutathione (GSH) levels in the mouse liver in the subacute cadmium intoxication model. NaQSA and NaMSA signicificantly counteracted cadmium-induced decreases in SOD and GSH levels. No significant differences in SOD and GSH levels between groups exposed to cadmium receiving NaQSA or/and NaMSA were observed

Mots clés: Cadmium intoxication; NaQSA; NaMSA; Morin; Quercetin; Flavonoids; GSH; SOD; Antioxidants

Ewa Chlebda, Jan Magdalan, Anna Merwid-Ląd, Małgorzata Trocha, Maria Kopacz, et al.. Influence of water-soluble flavonoids: Quercetin5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt on antioxidant parameters in the subacute cadmium intoxication mouse model. Experimental and Toxicologic Pathology, 2010, 62 (2), pp.105. ⟨10.1016/j.etp.2009.02.118⟩. ⟨hal-00564776⟩