The effects of mivacurium induced neuromuscular block on Bispectral Index and Cerebral State Index in children under propofol-anaesthesia – a prospective randomized clinical trial

Frank Weber (1) , Nadia Kriek (1) , Heleen J Blussé van Oud-Alblas (1)

1 Dep. of Anaesthesia

Background: In adults anaesthetised with propofol, muscle relaxants may decrease the Bispectral Index (BIS). The aim of this prospective randomized trial was to detect the influence of a muscle relaxant bolus on the BIS and the Cerebral State Index (CSI) in children under propofol anaesthesia. Methods: Forty paediatric patients, age 6.6±3.3 years, weight 24±9 kg, scheduled for surgical procedures requiring general anaesthesia were enrolled. Two minutes after i.v. injection of 0.3 mcg kg-1 of sufentanil general anaesthesia was induced by an initial bolus of 3 mg kg-1 of propofol, followed by a continuous infusion titrated to achieve a stable BIS value of 50±5. Patients received either mivacurium 0.25 mg kg-1 (Group Miva) or NaCl 0.9% 0.12 ml kg-1 (Group Con). Mean BIS and CSI values per minute were compared between (Miva vs. Con) and within groups (Baseline vs. 5 min. after study drug administration). Results: The observed changes in BIS and CSI values before and after administration of study drugs revealed no differences between the study groups. Mean baseline BIS- and CSI-values were lower than 5 minutes after study drug administration. There were no intergroup differences with respect to BIS and CSI values at any time point. Conclusions: These data suggest that in paediatric patients anaesthetised with propofol, administration of mivacurium has no impact on BIS-, and CSI- values.

Mots clés: Medicine

Frank Weber, Nadia Kriek, Heleen J Blussé van Oud-Alblas. The effects of mivacurium induced neuromuscular block on Bispectral Index and Cerebral State Index in children under propofol-anaesthesia – a prospective randomized clinical trial. Pediatric Anesthesia, 2010, 20 (8), pp.697. ⟨10.1111/j.1460-9592.2010.03327.x⟩. ⟨hal-00560695⟩