Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed

Y.E.A. van Riet (1) , A.J.G. Maaskant (1) , G.J. Creemers (2) , L. van Warmerdam (1) , F.H. Jansen (3) , C.J.H. van de Velde (4) , H.J.T. Rutten (1) , G.A.P. Nieuwenhuijzen (1)

1 Department of Surgery
2 Department of Medical Oncology
3 Department of Radiology
4 Department of Surgery

The use of neo-adjuvant chemotherapy has increased in the treatment of loco-regionally advanced primarily operable breast cancer. As a result of improved neo-adjuvant chemotherapy regimes the number of clinical as well as radiological responses have increased. In case of a complete response it is difficult to identify residual disease and to perform an adequate radical breast-conserving surgery. Therefore localization of the original tumour bed is mandatory. In this study we propose a novel technique with a seed containing radioactive 125 Iodine (I). The I has a half-time of 60 days and is therefore still recognisable with a gamma probe after admittance of several courses of neo-adjuvant chemotherapy.

Mots clés: I seed localization; Breast cancer; breast-conser`ving surgery; neo-adjuvant chemotherapy

Y.E.A. van Riet, A.J.G. Maaskant, G.J. Creemers, L. van Warmerdam, F.H. Jansen, et al.. Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed. EJSO - European Journal of Surgical Oncology, 2010, 36 (2), pp.164. ⟨10.1016/j.ejso.2009.10.009⟩. ⟨hal-00557772⟩