The Risk of Urothelial Bladder Cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers
Résumé
Background: Colorectal, endometrial and upper urinary tract tumours are characteristic for Lynch syndrome (HNPCC). The aim of the present study was to establish whether carriers of mutations in mismatch repair genes , or are at increased risk of urinary bladder cancer. Methods: Carriers and first-degree relatives of 95 families with a germline mutation in the (n=26), (n=43), or (n=26) gene were systematically questioned about the occurrence of carcinoma. The cumulative risk of cancer occurring before the age of 70 years (CR70) was compared to the CR70 of the general Dutch population. Microsatellite instability (MSI) testing and/or immuno-histo¬chemistry (IHC) for mismatch repair proteins was performed on bladder tumour tissue. Results: Bladder cancer was diagnosed in 21 patients (90% men) from 19 Lynch syndrome families (2 , 15 , and 4 ). CR70 for bladder cancer was 7.5% [95% CI 3.1-11.9%] for men and 1.0% [95% CI 0-2.4%] for women, resulting in relative risks for mutation carriers and first-degree relatives of 4.2 [95% CI 2.2-7.2] for men and 2.2 [95% CI 0.3-8.0] for women. Men carrying an mutation and their first-degree relatives were at highest risks: CR70 for bladder and upper urinary tract cancer being 12.3% [95% CI 4.3-20.3%] and 5.9% [95% CI 0.7-11.1%]. Bladder cancer tissue was MSI positive in 6/7 tumours and loss of IHC staining was found in 14/17 tumours, indicating Lynch syndrome aetiology. Conclusion: Patients with Lynch syndrome carrying an mutation are at increased risk of urinary tract cancer including bladder cancer. In these cases surveillance should be considered.
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