Titin-induced force enhancement and force depression: A ‘sticky-spring' mechanism in muscle contractions?

Christian Rode (1) , Tobias Siebert (1) , Reinhard Blickhan (1)

1 Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany]

The sliding filament and crossbridge theories do not suffice to explain a number of muscle experiments. For example, from the entire muscle to myofibrils, predictions of these theories were shown to underestimate the force output during and after active tissue stretch. The converse applies to active tissue shortening.

Mots clés: Molecular mechanism; Model; Stretch; Shortening; Sarcomere; Myofilament interaction

Christian Rode, Tobias Siebert, Reinhard Blickhan. Titin-induced force enhancement and force depression: A ‘sticky-spring' mechanism in muscle contractions?. Journal of Theoretical Biology, 2009, 259 (2), pp.350. ⟨10.1016/j.jtbi.2009.03.015⟩. ⟨hal-00554591⟩