Pro-inflammatory cell stress in sIBM muscle: overexpression of αB-crystallin is associated with APP and accumulation of β-amyloid

Ingrid E Muth (1) , Konstanze Barthel (1) , Mathias Bähr (1) , Marinos C Dalakas (2) , Jens Schmidt (1)

1 UMG - University Medical Center Göttingen
2 Imperial College London

In the pathology of sIBM, the relevance of cell-stress molecules such as the heat-shock-protein αB-crystallin, particularly in healthy appearing muscle fibres, has remained elusive.

Mots clés: AMYLOID; INCL BODY MYOSITIS; MYOPATHY

Ingrid E Muth, Konstanze Barthel, Mathias Bähr, Marinos C Dalakas, Jens Schmidt. Pro-inflammatory cell stress in sIBM muscle: overexpression of αB-crystallin is associated with APP and accumulation of β-amyloid. Journal of Neurology, Neurosurgery and Psychiatry, 2009, 80 (12), pp.1344. ⟨10.1136/jnnp.2009.174276⟩. ⟨hal-00552774⟩