Hippocampal sclerosis in refractory temporal lobe epilepsy is associated with gluten sensitivity

Maria Peltola (1) , Katri Kaukinen (2) , Prasun Dastidar (3) , Katri Haimila (4) , Jukka Partanen (4) , Anna-Maija Haapala (5) , Markku Mäki (6) , Tapani Keränen (7) , Jukka Peltola (8)

1 Medical school, University of Tampere
2 Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital
3 Department of Radiology, Tampere University Hospital
4 Department of Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service
5 Department of Clinical Microbiology, Center for Laboratory Medicine, Tampere University Hospital
6 Department of Pediatrics, Tampere University Hospital
7 Department of Neurology and Rehabilitation, Tampere University Hospital
8 Tampere University Hospital

Previously coeliac disease (CD) and gluten sensitivity (defined as the presence of anti-gliadin antibodies and positive immunogenetics) has been associated with cerebellar degeneration and epilepsy with occipital calcifications. Hippocampal sclerosis (HS) in temporal lobe epilepsy (TLE) is a potentially progressive disorder with unknown aetiology, and autoimmunity has been implicated in TLE+HS as one of the possible mechanism leading to HS.The purpose of this study is to analyze CD associated antibodies and gluten sensitivity in well characterized group of patients with refractory focal epilepsy.

Mots clés: EPILEPSY; coeliac disease; gluten sensitivity; hippocampal sclerosis; temporal lobe epilepsy

Maria Peltola, Katri Kaukinen, Prasun Dastidar, Katri Haimila, Jukka Partanen, et al.. Hippocampal sclerosis in refractory temporal lobe epilepsy is associated with gluten sensitivity. Journal of Neurology, Neurosurgery and Psychiatry, 2009, 80 (6), pp.626. ⟨10.1136/jnnp.2008.148221⟩. ⟨hal-00552710⟩