Replication of Restless Legs Syndrome Loci in Three European Populations

David Kemlink (1) , Olli Polo (2) , Birgitte Frauscher (3) , Viola Gschlieser (3) , Birgitte Högl (3) , Werner Poewe (3) , Pavel Vodicka (4) , Jana Vavrova (1) , Karel Sonka (1) , Sona Nevsimalova (1) , Barbara Schormair (5) , Peter Lichtner (5) , Kaisa Silander (6) , Lena Peltonen (6) , Christian Gieger (7) , H-Erich Wichmann (7) , Alexander Zimprich (8) , Darina Roeske (9) , Bertram Müller-Myhsok (9) , Thomas Meitinger (5) , Juliane Winkelmann (5)

1 Laboratoire d'étude des maladies du cerveau
2 Sleep Research Unit
3 Department of Neurology
4 Department of Neurology
5 IHG - Institute of Human Genetics [Neuherberg]
6 Department of Neurology
7 EPI - Institute of Epidemiology [Neuherberg]
8 Centre for Molecular Medicine and Therapeutics
9 Max Planck Institute of Psychiatry

Restless legs syndrome (RLS) is associated to common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q.

Mots clés: Neurology; Genetic epidemiology; Association studies; Restless legs syndrome

David Kemlink, Olli Polo, Birgitte Frauscher, Viola Gschlieser, Birgitte Högl, et al.. Replication of Restless Legs Syndrome Loci in Three European Populations. Journal of Medical Genetics, 2009, 46 (5), pp.315. ⟨10.1136/jmg.2008.062992⟩. ⟨hal-00552671⟩