Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP)

Felix Wantke (1) , Meinhard Kneussl (1) , Marianne Hubner (1) , Kurt Derfler (2) , Thomas Brücke (3) , Sabine Schmaldienst (2)

1 Department of Pneumonology
2 Division of Nephrology and Dialysis
3 Department of Neurology

We report of a 46-year-old female patient with cryptogen organizing pneumonia preceeding the rare SRP positive necrotising myositis without cardiac involvement and no sign of dysphagia. Myositis showed full regression without oral immune suppression but with extracorporeal treatment, performed as a combined therapy of plasmaexchange and immunoadsorption. After 33-month of treatment, anti-SRP antibodies were not detectable any more.

Mots clés: Autoimmune myositis; Signal recognition particle; Cryptogen organizing pneumonia; Plasmaexchange; Immunoadsorption

Felix Wantke, Meinhard Kneussl, Marianne Hubner, Kurt Derfler, Thomas Brücke, et al.. Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP). Rheumatology International, 2009, 30 (10), pp.1361-1365. ⟨10.1007/s00296-009-1059-4⟩. ⟨hal-00552490⟩