Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells

Seema-Maria Nathwani (1) , Stephen Butler (2) , Darren Fayne (3) , Naomi N. Mcgovern (1) , Balazs Sarkadi (4) , Mary J. Meegan (2) , David G. Lloyd (3) , Giuseppe Campiani (5) , Mark Lawler (6) , D. Clive Williams (1) , Daniela M. Zisterer (1)

1 School of Biochemistry and Immunology
2 School of Pharmacy and Pharmaceutical Sciences
3 Molecular Design Group, School of Biochemistry and Immunology
4 Membrane Research Group of Hungarian Academy of Sciences
5 European Research Centre for Drug Discovery and Development, Banchi di Sotto 55 and Dipartimento Farmaco Chimico Tecnologico
6 Institute of Molecular Medicine

Mots clés: PBOX; Microtubule-targeting agents; Multi-drug resistance (MDR); P-glycoprotein; BCRP

Seema-Maria Nathwani, Stephen Butler, Darren Fayne, Naomi N. Mcgovern, Balazs Sarkadi, et al.. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells. Cancer Chemotherapy and Pharmacology, 2009, 66 (3), pp.585-596. ⟨10.1007/s00280-009-1200-9⟩. ⟨hal-00552484⟩