Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines

Sara Nannizzi (1) , Gareth J. Veal (2) , Elisa Giovannetti (1, 3) , Valentina Mey (1) , Simona Ricciardi (1) , Christopher J. Ottley (4) , Mario Tacca (1) , Romano Danesi (1)

1 Division of Pharmacology and Chemotherapy, Department of Internal Medicine
2 Northern Institute for Cancer Research, Medical School
3 Department of Medical Oncology
4 Department of Earth Sciences [Durham]

Mots clés: Colon cancer; Oxaliplatin; Pemetrexed; Gene expression; DNA repair; DNA adducts

Sara Nannizzi, Gareth J. Veal, Elisa Giovannetti, Valentina Mey, Simona Ricciardi, et al.. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer Chemotherapy and Pharmacology, 2009, 66 (3), pp.547-558. ⟨10.1007/s00280-009-1195-2⟩. ⟨hal-00552482⟩