A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL OF THE EFFECT OF ω-3 FATTY ACIDS ON OXIDATIVE STRESS OF PRETERM NEONATES FED THROUGH PARENTERAL NUTRITION

Maria Skouroliakou (1) , Dimitris Konstantinou (1) , Katerina Koutri (1) , Christina Kakavelaki (1) , Maria Stathopoulou (1) , Marina Antoniadi (1) , Nikolaos Xemelidis (1) , Victoria Kona (1) , Markantonis Sophia (1)

1 Dietetics and Nutrition

Background/Objectives: The aim of this study was to research and draw conclusions about the effect of a parenteral nutrition (PN) fat emulsion, rich in ω-3 fatty acids, on the antioxidant markers of preterm infants, when compared with a standard fat emulsion. That was a double-blind, parallel-group study conducted in Athens, Greece, using an equal randomisation method. Subjects/Methods: Thirty eight infants were selected using a double-blind method and one computer-generated randomization list. Both groups received PN based on the same protocols. Group A received SMOFlipid fat emulsion, while group B received the standard fat emulsion (Intralipid). Serum levels of vitamins A, E and total antioxidant potential (TAP) were measured on days 0, 7 and 14 of PN support. Clinical and biochemical data were collected on days 0, 14 and the day of discharge. Results: Serum levels of vitamins E and A were significantly increased in group A, while only vitamin A was increased in group B, on the 14th day (Group A: vitamin E: p-value=0.002, vitamin A: p-value=0.000, Group B: vitamin E: p-value=0.065, vitamin A: p-value=0.000). TAP was increased only in the intervention group (Group A: p-value=0.000, Group B: p-value=0.287). Mild anaemia was developed in both groups, while no differences were detected in infection rate, days of hospitalization, days of ventilator support and days of phototherapy. Conclusions: Oxidative stress was significantly reduced in those neonates fed with ω-3 fatty acids, while no effect was observed in the neonates fed with standard lipids. Intervention had no effect on infants' growth and clinical outcome.

Mots clés: preterm neonates; oxidative stress; total antioxidant potential; ω-3 fatty acids; parenteral nutrition

Maria Skouroliakou, Dimitris Konstantinou, Katerina Koutri, Christina Kakavelaki, Maria Stathopoulou, et al.. A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL OF THE EFFECT OF ω-3 FATTY ACIDS ON OXIDATIVE STRESS OF PRETERM NEONATES FED THROUGH PARENTERAL NUTRITION. European Journal of Clinical Nutrition, 2010, ⟨10.1038/ejcn.2010.98⟩. ⟨hal-00547308⟩