Mitochondria as ATP Consumers in Cellular Pathology

Christos Chinopoulos , Vera Adam-Vizi

ATP provided by oxidative phosphorylation supports highly complex and energetically expensive cellular processes. Yet, in several pathological settings, mitochondria could revert to ATP consumption, aggravating an existing cellular pathology. Here we review: i) the pathological conditions leading to ATP hydrolysis by the reverse operation of the mitochondrial FoF1-ATPase, ii) molecular and thermodynamic factors influencing the directionality of the FoF1-ATPase iii) the role of the adenine nucleotide translocase as the intermediary adenine nucleotide flux pathway between the cytosol and the mitochondrial matrix when mitochondria become ATP consumers, iv) the role of the permeability transition pore in bypassing the ANT, thereby allowing the flux of ATP directly to the hydrolyzing FoF1-ATPase v) the impact of the permeability transition pore on glycolytic ATP production, and vi) endo-and exogenous interventions for limiting ATP hydrolysis by the mitochondrial FoF1-ATPase.

Mots clés: Life Sciences

Christos Chinopoulos, Vera Adam-Vizi. Mitochondria as ATP Consumers in Cellular Pathology. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2009, 1802 (1), pp.221. ⟨10.1016/j.bbadis.2009.08.008⟩. ⟨hal-00543007⟩