Comparative analysis of the sialic acid binding activity of four different IBV strains

Sahar Abd El Rahman (1) , Ali Ali Ibrahim El-Kenawy (2) , Ulrich Neumann (3) , Georg Herrler (1) , Christine Winter (4)

1 Institute of Virology
2 virology department
3 TIHO - Clinic for Poultry
4 Institute of Virology

Avian infectious bronchitis virus (IBV) is a major pathogen in commercial poultry flocks. Recently we demonstrated, that sialic acid serves as a receptor determinant for IBV on the tracheal epithelium. Here we compared the IBV strains Beaudette, 4/91, Italy02, and QX for their sialic acid binding properties. We demonstrate that sialic acid binding is important for the infection of primary chicken kidney cells and the tracheal epithelium by all four strains. There were only slight differences between the four strains, indicating the universal usage of sialic acids as receptor determinants by IBV.

Mots clés: Life Sciences

Sahar Abd El Rahman, Ali Ali Ibrahim El-Kenawy, Ulrich Neumann, Georg Herrler, Christine Winter. Comparative analysis of the sialic acid binding activity of four different IBV strains. Avian Pathology, 2009, 38 (01), pp.41-45. ⟨10.1080/03079450802632049⟩. ⟨hal-00540140⟩