Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily

Mikko Kuoppamäki (1, 2) , Kirsi Korpela (3) , Reijo Marttila (2) , Valtteri Kaasinen (2, 4) , Päivi Hartikainen (5) , Jukka Lyytinen (6) , Seppo Kaakkola (6) , Jutta Hänninen (1) , Eliisa Löyttyniemi (1) , Marita Kailajärvi (7) , Päivi Ruokoniemi (7) , Juha Ellmén (1)

1 Orion Pharma
2 Department of Neurology
3 Orion Pharma
4 Turku PET Centre
5 KUH - Kuopio University Hospital
6 Department of Neurology
7 Clinical Research Services Turku (CRST), and Unit of Clinical Pharmacology, TYKSLAB, Hospital District of Southwest Finland

Mots clés: Pharmacokinetics; Levodopa; Carbidopa; Entacapone; Parkinson's disease

Mikko Kuoppamäki, Kirsi Korpela, Reijo Marttila, Valtteri Kaasinen, Päivi Hartikainen, et al.. Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily. European Journal of Clinical Pharmacology, 2009, 65 (5), pp.443-455. ⟨10.1007/s00228-009-0622-y⟩. ⟨hal-00534945⟩