Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993-2005

Simona de Grazia (1) , Vito Martella (2, 3) , Claudia Colomba (1) , Antonio Cascio (4) , Serenella Arista (1) , Giovanni Maurizio Giammanco (1)

1 Department of Health Promotion Sciences
2 Public Health and Animal Sciences
3 Public Health and Animal Sciences
4 Clinica delle Malattie Infettive

In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6 and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4 and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein.

Mots clés: Medicine

Simona de Grazia, Vito Martella, Claudia Colomba, Antonio Cascio, Serenella Arista, et al.. Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993-2005. Journal of Medical Virology, 2009, 81 (12), pp.2089. ⟨10.1002/jmv.21615⟩. ⟨hal-00531824⟩