Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers

Sebastien Benzekry (1, 2)

1 LATP - Laboratoire d'Analyse, Topologie, Probabilités
2 IP-TPT - Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques

We introduce and analyze a phenomenological model for anti-angiogenic therapy in the treatment of metastatic cancers. It is a structured transport equation with a nonlocal boundary condition describing the evolution of the density of metastasis that we analyze first at the continuous level. We present the numerical analysis of a lagrangian scheme based on the characteristics whose convergence establishes existence of solutions. Then we prove an error estimate and use the model to perform interesting simulations in view of clinical applications.

Mots clés: Anticancer therapy modelling; Angiogenesis; Structured population dynamics; Lagrangian scheme

Domaines: Equations aux dérivées partielles [math.AP]; Cancer

Sebastien Benzekry. Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers. ESAIM: Mathematical Modelling and Numerical Analysis, 2012, 46 (2), pp.207-237. ⟨hal-00518110⟩