Successful combination treatment of clofarabine, cytarabine and gemtuzumab-ozogamicin in adult refractory B-acute lymphoblastic leukemia

Cristina Papayannidis (1) , Enrico Derenzini (1) , Ilaria Iacobucci (1) , Antonio Curti (1) , Stefania Paolini (1) , Daniela Cilloni (2) , Michele Baccarani (1) , Giovanni Martinelli (1)

1 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
2 Department of Clinical and Biological Sciences

Despite relevant advances in survival rates of pediatric acute lymphoblastic leukemia (ALL), in adult patients the outcome is still dismal, due to a greater drug resistance, a poorer compliance with treatment, and less effective current therapies. The need for more active agents has identified a novel purine nucleoside analogue, clofarabine, which has been approved for the treatment of children with relapsed and refractory ALL, showing also promising clinical benefit in phase I-II studies in adult patients.

Mots clés: Medicine

Cristina Papayannidis, Enrico Derenzini, Ilaria Iacobucci, Antonio Curti, Stefania Paolini, et al.. Successful combination treatment of clofarabine, cytarabine and gemtuzumab-ozogamicin in adult refractory B-acute lymphoblastic leukemia. American Journal of Hematology, 2009, 84 (12), pp.849. ⟨10.1002/ajh.21548⟩. ⟨hal-00517921⟩