Long-lived fluorescence of homopolymeric guanine–cytosine DNA duplexes

I. Vayá (1) , P. Changenet-Barret (1) , T. Gustavsson (1) , D. Zikich (2) , A. B. Kotlyar (2) , D. Markovitsi (1)

1 LFP - URA 2453 - Laboratoire Francis PERRIN
2 Georges S.Wise Faculty of Life Sciences

The fluorescence spectrum of the homopolymeric double helix poly(dG)·poly(dC) is dominated by emission decaying on the nanosecond time-scale, as previously reported for the alternating homologue poly(dGdC)·poly(dGdC). Thus, energy trapping over long periods of time is a common feature of GC duplexes which contrast with AT duplexes. The impact of such behaviour on DNA photodamage needs to be evaluated.

Domaines: Chimie théorique et/ou physique

I. Vayá, P. Changenet-Barret, T. Gustavsson, D. Zikich, A. B. Kotlyar, et al.. Long-lived fluorescence of homopolymeric guanine–cytosine DNA duplexes. Photochemical & Photobiological Sciences , 2010, 9, pp.1193-1195. ⟨10.1039/C0PP00201A⟩. ⟨hal-00516381⟩