Ovariectomy and estrogen treatment modulate iron metabolism in rat adipose tissue

Giuseppina Mattace Raso , Carlo Irace , Emanuela Esposito , Carmen Maffettone , Anna Iacono , Antonio Di Pascale , Rita Santamaria , Alfredo Colonna , Rosaria Meli

Iron is essential for many biological processes and its deficiency or excess is involved in pathological conditions. At cellular level, the maintenance of iron homeostasis is largely accomplished by the transferrin receptor (TfR)-1 and by ferritin, whose expression is mainly regulated post-transcriptionally by Iron Regulatory Proteins (IRPs).

Mots clés: estrogen; ovariectomy; adipose tissue; iron metabolism; iron regulatory proteins

Giuseppina Mattace Raso, Carlo Irace, Emanuela Esposito, Carmen Maffettone, Anna Iacono, et al.. Ovariectomy and estrogen treatment modulate iron metabolism in rat adipose tissue. Biochemical Pharmacology, 2009, 78 (8), pp.1001. ⟨10.1016/j.bcp.2009.05.034⟩. ⟨hal-00514595⟩