An artificial sodium ion channel from calix[4]arene in the 1,3-alternate conformation

Peter J. Cragg (1) , Olasupo Lawal (2) , Khayzuran Iqbal (2) , Ali Mohamadi (2) , Parichehr Razavi (2) , Howard Dodd (2) , Marcus Allen (2) , Samreen Siddiqui (2) , Flavia Fucassi (2)

1 University of Brighton
2 School of Pharmacy and Biomolecular Sciences

The synthesis of a calix[4]arene with pendent polyether substituents is described. The compound was shown by NMR to bind Na+ when in the 1,3-alternate conformation and computational simulations suggest metal binding within the calixarene annulus. 1H NMR indicated that the complexed cation attracts water and the formation of a stable dehydrate was also indicated by in silico methods. Lipid bilayer experiments confirmed that the 1,3-alt calixarene functions as an artificial transmembrane ion in the presence of Na+ but not K+.

Mots clés: Physical Sciences

Peter J. Cragg, Olasupo Lawal, Khayzuran Iqbal, Ali Mohamadi, Parichehr Razavi, et al.. An artificial sodium ion channel from calix[4]arene in the 1,3-alternate conformation. Supramolecular Chemistry, 2009, 21 (01-02), pp.55-60. ⟨10.1080/10610270802528307⟩. ⟨hal-00513548⟩