Structural and functional diversity of native brain neuronal nicotinic receptors

Cecilia Gotti , Francesco Clementi , Alice Fornari , Annalisa Gaimarri , Stefania Guiducci , Irene Manfredi , Milena Moretti , Patrizia Pedrazzi , Luca Pucci , Michele Zoli

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono-and divalent cations. They share a common basic structure but their pharmacological and functional properties arise from the wide range of different subunit combinations making up distinctive subtypes.

Mots clés: Neuronal nicotinic receptors; Subtypes; Subunit composition; Stochiometry; Meso-striatal pathway; Habenulo-interpeduncular pathway

Cecilia Gotti, Francesco Clementi, Alice Fornari, Annalisa Gaimarri, Stefania Guiducci, et al.. Structural and functional diversity of native brain neuronal nicotinic receptors. Biochemical Pharmacology, 2009, 78 (7), pp.703. ⟨10.1016/j.bcp.2009.05.024⟩. ⟨hal-00509504⟩