Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet
Résumé
Background: Understanding the absorption and excretion of dietary flavonoids is fundamental in determining their biological activity. Objective: To determine biokinetic pattern of the flavonoids quercetin, hesperetin and naringenin given simultaneously, in equal amounts as part of the diet. Design: Ten healthy men excluded flavonoid containing foods and beverages 48 h before and after consumption of a flavonoid-rich juice. Urine and plasma samples were collected prior to and 48h after dosing with the flavonoid rich juice. The samples were analyzed by column-switching liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry (LC-MS). Results: Mean plasma AUC0-48h and Cmax values for quercetin and hesperetin were not significantly different. However, AUC0-48h and Cmax values, but not Tmax, were higher for naringenin after consumption of the same dose. The total urinary excretion for quercetin (1.5% 1%) was lower than for hesperetin (14.2% 9.1%) and naringenin (22.6% 11.5%). Conclusion: The relative bioavailability of quercetin and hesperetin, expressed as AUC0-48h, were similar, whereas the relative bioavailability was significantly higher for naringenin after simultaneously consumption of the same dose. The study consolidates a lower urinary excretion of quercetin compared to hesperetin and naringenin despite a similar plasma concentration.
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