Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways

Ana Gomes , Eduarda Fernandes , Artur M.S. Silva , Clementina M.M. Santos , Diana C.G.A. Pinto , José A.S. Cavaleiro , José L.F.C. Lima

Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of prostaglandins (PGs), in particular PGE and PGI, which are pro-inflammatory mediators.

Mots clés: 2-Styrylchromones; Cyclooxygenase; 5-Lipoxigenase; Leukotriene B; Dual inhibitors; Inflammation

Ana Gomes, Eduarda Fernandes, Artur M.S. Silva, Clementina M.M. Santos, Diana C.G.A. Pinto, et al.. Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways. Biochemical Pharmacology, 2009, 78 (2), pp.171. ⟨10.1016/j.bcp.2009.03.028⟩. ⟨hal-00493512⟩