Common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors
Résumé
Recently, the genetic variant Y402H in complement factor H gene (CFH) was associated with increased risk for myocardial infarction (MI) in a prospective Caucasian cohort. In another nested case-control study, however, the CFH-Y402H variant did not carry susceptibility to MI. The aim of the present study was to test for association between the CFH-Y402H variant and MI in a large case-control sample with familial background for coronary artery disease (CAD). A total of 2,161 individuals from the German MI family study were studied by questionnaire, physical examination and biochemical analyses. MI patients (n=1,188; 51.4 ± 8.6 years at first MI) were recruited from families with at least two members affected by MI and/or severe CAD. Spouses, sisters-in-law, and brothers-in-law, respectively, without MI/CAD were included as unaffected controls (n=973; 56.9 ± 9.8 years). Genotyping was performed using a TaqMan assay. Common Y402H variant in the CFH gene was not associated with classical cardiovascular risk factors (diabetes, hypercholesterolemia, hypertension, obesity, smoking, and C-reactive protein serum levels). No association could be found between the CFH-Y402H variant and susceptibility to MI. Separate analyses in both men and women revealed no gender-specific influence of the gene variant on cardiovascular risk factors or MI. This investigation could not replicate the association between the common CFH-Y402H variant and susceptibility to MI in our large Caucasian population which is enriched for genetic factors. We conclude that the CFH-Y402H variant has no relevant risk modifying effect in our population.
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