{beta}-Adrenergic receptor blockers and the treatment of vasovagal syncope: more nails in the coffin!

Christopher J Mathias (1)

1 Neurovascular Medicine Unit

{beta}-adrenergic receptor blockers are one of a number of therapeutic agents promoted as having beneficial effects in vasovagal syncope. In this issue of Clinical Science, Eldadah and co-workers have investigated the effect of the {beta}-adrenergic receptor blocker propranolol in preventing syncope in a double-blind cross-over trail in eight subjects with a diagnosis based on tilt table testing and elevated plasma adrenaline levels during syncope. Of these, seven did not respond and the authors therefore suggest that this drug has no role in the management of vasovagal syncope. Their laboratory-based study, however, raises a number of issues regarding terminology, choice of subjects, the value and role of investigations directed towards diagnosis and in understanding pathophysiological mechanisms and the relevance of such trial to individual subjects with vasovagal syncope.

Mots clés: Medicine

Christopher J Mathias. {beta}-Adrenergic receptor blockers and the treatment of vasovagal syncope: more nails in the coffin!. Clinical Science, 2006, 111 (3), pp.189-191. ⟨10.1042/CS20060174⟩. ⟨hal-00479333⟩