Local inflammation, endothelial dysfunction and fibrinolysis in coronary heart disease

Gordon Do Lowe (1)

1 University Department of Medicine

Prospective epidemiological studies have shown associations of circulating inflammatory markers with risk of coronary heart disease (CHD); however these associations are modest after adjustment for confounding by established risk factors, and do not add significantly to the predictive value of current clinical risk scores. In contrast, experimental human studies of local arterial inflammation (such as the brachial artery infusion of TNFa model reported by Robinson et al) are of value in elucidating the pathophysiology of atherothrombosis.

Mots clés: Medicine

Gordon Do Lowe. Local inflammation, endothelial dysfunction and fibrinolysis in coronary heart disease. Clinical Science, 2006, 110 (3), pp.327-328. ⟨10.1042/CS20060002⟩. ⟨hal-00479319⟩