Structural characterization of Sol-Gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties.

Guillaume Renaudin (1) , Patrice Laquerriere (2) , Yaroslav Fillinchuk (3) , Edouard Jallot (4) , Jean-Marie Nedelec (1)

1 LMI - Laboratoire des Matériaux Inorganiques
2 Interfaces biomatériaux/tissus hôtes
3 ESRF - European Synchrotron Radiation Facility
4 LPC - Laboratoire de Physique Corpusculaire - Clermont-Ferrand

Sol-Gel chemistry has been successfully used to prepare un-doped and Sr-doped calcium phosphate ceramics exhibiting a porous structure. The samples composition is very close to the nominal one. All samples present phase mixtures mainly Hydroxyapatite (HAp) and Tri Calcium Phosphate (Β-TCP). Doping with Sr2+ ions has a clear effect on the proportions of the different phases, increasing the amount of Β-TCP. An amorphous phase is also observed incorporating some 40 % of the total amount of strontium. Strontium ions also substitute for calcium both in HAp and Β-TCP in specific sites that have been determined from Rietveld refinement on synchrotron powder diffraction data. The soluble amorphous and TCP phases are responsible for a beneficial partial release of strontium ions in solution during interactions between the material and biological fluids. Preliminary in vitro study demonstrates anti-inflammatory effect of strontium for human monocytes cultured in contact with calcium phosphates.

Mots clés: biomaterials; hydroxyapatite; strontium; osteoporosis

Domaines: Matériaux

Guillaume Renaudin, Patrice Laquerriere, Yaroslav Fillinchuk, Edouard Jallot, Jean-Marie Nedelec. Structural characterization of Sol-Gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties.. Journal of Materials Chemistry, 2008, 18, pp.3593-3600. ⟨10.1039/b804140g⟩. ⟨hal-00360355⟩