Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.

Marie-Laure Teyssot (1) , Anne-Sophie Jarrousse (2) , Aurélien Chevry (1) , Angélique de Haze (2) , Claude Beaudoin (2) , Michèle Manin (2) , Steven P. Nolan (3) , Silvia Diez-Gonzalez (3) , Laurent Morel (2) , Arnaud Gautier (1)

1 SEESIB - Synthèse et étude de systèmes à intêret biologique
2 GReD - Génétique, Reproduction et Développement
3 ICIQ - Institute of Chemical Research of Catalonia

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Mots clés: Antitumor agents; apoptosis; carbenes; cell cycle

Domaines: Chimie organique

Marie-Laure Teyssot, Anne-Sophie Jarrousse, Aurélien Chevry, Angélique de Haze, Claude Beaudoin, et al.. Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.. Chemistry - A European Journal, 2009, 15 (2), pp.314-8. ⟨10.1002/chem.200801992⟩. ⟨hal-00352346⟩