Our favourite alternative splice site.

Hubert Lerivray (1) , Agnès Méreau (1) , Howard Beverley Osborne (1)

1 IGDR - Institut de Génétique et Développement de Rennes

Alternative splicing is a widespread mechanism in mammals that generates several mRNAs from one gene, thereby creating genetic diversity of the genome. Variant splice patterns are often specific to different stages of development or particular tissues, and alternative splicing defects are being more frequently detected in genetic diseases and cancers. The increasingly important role of alternative splicing in the function and the regulation of cellular process makes it critical to have an easy-to-use data repository for the biological and medical research communities. We have compared web resources that give access to information on alternatively spliced genes, and the FAST DB (Friendly Alternative Splicing and Transcripts DataBase) site came out as our favourite.

Domaines: Biochimie, Biologie Moléculaire

Hubert Lerivray, Agnès Méreau, Howard Beverley Osborne. Our favourite alternative splice site.. Biology of the Cell, 2006, 98 (5), pp.317-21. ⟨10.1042/BC20050084⟩. ⟨hal-00307730⟩