Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect

B. Goffinet (1) , P. Le Roy (2) , D. Boichard (2) , J.M. Elsen (3) , B. Mangin (1)

1 UBIA - Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT)
2 SGQA - Station de Génétique Quantitative et Appliquée
3 SAGA - Station d'Amélioration Génétique des Animaux

This paper describes two kinds of alternative models for QTL detection in livestock: an heteroskedastic model, and models corresponding to several hypotheses concerning the distribution of the QTL substitution effect among the sires: a fixed and limited number of alleles or an infinite number of alleles. The power of different tests built with these hypotheses were computed under different situations. The genetic variance associated with the QTL was shown in some situations. The results showed small power differences between the different models, but important differences in the quality of the estimations. In addition, a model was built in a simplified situation to investigate the gain in using possible linkage disequilibrium.

Mots clés: HALF-SIB FAMILIES; HETEROSKEDASTIC MODEL; LINKAGE DISEQUILIBRIUM; QTL DETECTION; FAMILLE DE DEMI-FRERES; MODELE HETEROSCEDASTIQUE; DESEQUILIBRE DE LIAISON; DETECTION DE QTL

Domaines: Génétique animale

B. Goffinet, P. Le Roy, D. Boichard, J.M. Elsen, B. Mangin. Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect. Genetics Selection Evolution, 1999, 31, pp.341-350. ⟨hal-00199755⟩