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| HAL : hal-00174449, version 1 |
| arXiv : cond-mat/0610372 |
| DOI : 10.1016/j.nimb.2007.03.092 |
| Fiche détaillée |  Récupérer au format |
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| Nuclear Instruments and Methods in Physics Research Research Section B: Beam Interactions with Materials and Atoms 261 (2007) 488-493 |
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| Biological activity of a SiO2-CaO-P2O5 sol-gel glass highlighted by PIXE-RBS methods |
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| J. Lao 1Jean-Marie Nedelec 2 |
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| (2007) |
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| It is proposed in this study to observe the influence of P2O5 on the formation of the apatite-like layer in a bioactive glass via a complete PIXE characterization. A glass in the SiO2-CaO-P2O5 ternary system was elaborated by sol-gel processing. Glass samples were soaked in biological fluids for periods up to 10 days. The surface changes were characterized using Particle Induced X-ray Emission (PIXE) associated to Rutherford Backscattering Spectroscopy (RBS), which are efficient methods for multielemental analysis. Elemental maps of major and trace elements were obtained at a micrometer scale and revealed the bone bonding ability of the material. The formation of a calcium phosphate-rich layer containing magnesium occurs after a few days of interaction. We demonstrate that the presence of phosphorus in the material has an impact on the development and the formation rate of the bone-like apatite layer. Indeed, the Ca/P atomic ratio at the glass/biological fluids interface is closer to the nominal value of pure apatite compared to P2O5 free glasses. It would permit, in vivo, an improved chemical bond between the biomaterials and bone. |
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| 1 : | Laboratoire de Physique Corpusculaire de Clermont-Ferrand (LPC-CLERMONT) |
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CNRS : UMR6533 – IN2P3 – Université Blaise Pascal - Clermont-Ferrand II |
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| 2 : | Laboratoire des Matériaux Inorganiques (LMI) |
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CNRS : UMR6002 – Université Blaise Pascal - Clermont-Ferrand II – Clermont Université – Ecole Nationale Supérieure de Chimie de Clermont-Ferrand |
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| 3 : | Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG) |
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CNRS : UMR5797 – IN2P3 – Université Sciences et Technologies - Bordeaux I |
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| Domaine | : | Chimie/Matériaux Physique/Matière Condensée/Science des matériaux Physique/Physique/Biophysique |
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| PIXE-RBS methods – biomaterials – bioactive glass – sol-gel |
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| Liste des fichiers attachés à ce document : | |||||
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| hal-00174449, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00174449 | |
| oai:hal.archives-ouvertes.fr:hal-00174449 | |
| Contributeur : Jean-Marie Nedelec | |
| Soumis le : Lundi 24 Septembre 2007, 13:53:34 | |
| Dernière modification le : Vendredi 4 Juillet 2008, 14:31:50 | |
