Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

Anna Salvati (1) , Sandra Ristori (1) , Daniela Pietrangeli (2) , Julian Oberdisse (3) , Luca Calamai (4) , Giacomo Martini (1) , Giampaolo Ricciardi (2)

1 DICUS UniFI - Dipartimento di Chimica 'Ugo Schiff' [Sesto Fiorentino]
2 Department of Chemistry, Basilicata
3 LCVN - Laboratoire des colloïdes, verres et nanomatériaux
4 Department of Soil Science and Plant Nutrition, Firenze

The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine]magnesium(II) complex, MgHECSPz, is described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and ζ potential measurements in order to define the overall properties and structural details of loaded liposomes.

Domaines: Matière Molle [cond-mat.soft]; Biophysique [physics.bio-ph]

Anna Salvati, Sandra Ristori, Daniela Pietrangeli, Julian Oberdisse, Luca Calamai, et al.. Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study. 2007. ⟨hal-00170261⟩