Immunostimulating properties and three-dimensional structure of two tripeptides from human and cow caseins

Jean Berthou (1) , D. Migliore-Samour (2) , Alain Lifchitz (1) , Jean Delettré (1) , D. Floc'H (3) , Pierre Jollès (2)

1 LMCP - Laboratoire de minéralogie, cristallographie de Paris
2 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
3 Rhône-Poulenc Santé, Centre de Recherches de Vitry

Some tripeptides obtained by enzymic digestion of caseins possess immunomodulating properties. In order to correlate activity and structure, X-ray analysis has been applied to two of them Leu-Leu-Tyr and Gly-Leu-Phe.

Mots clés: Immunostimulation; Casein; Immunomodulating tripeptide; 3-dimensional structure

Domaines: Biochimie [q-bio.BM]; Science des matériaux [cond-mat.mtrl-sci]

Jean Berthou, D. Migliore-Samour, Alain Lifchitz, Jean Delettré, D. Floc'H, et al.. Immunostimulating properties and three-dimensional structure of two tripeptides from human and cow caseins. FEBS Letters, 1987, 218 (1), pp.55-58. ⟨10.1016/0014-5793(87)81017-7⟩. ⟨hal-00019883⟩