Dietary inflammatory potential and arterial stiffness in a French cohort: Insights from the STANISLAS study

Louis-Désiré Agbo (1, 2, 3, 4) , Nicolas Girerd (1, 2, 3, 4) , Zohra Lamiral (1, 2, 3, 4) , Kevin Duarte (1, 2, 3, 4) , Erwan Bozec (1, 2, 3, 4) , Ludovic Merckle (1, 2, 3, 4) , Axelle Hoge (5) , Michèle Guillaume (5) , Martine Laville (6, 7) , Julie-Anne Nazare (6, 7) , Patrick Rossignol (1, 2, 3, 4, 8, 9) , Jean-Marc Boivin (1, 2, 3, 4) , Sandra Wagner (1, 2, 3, 4)

1 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
2 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
3 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
4 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
5 Université de Liège
6 CRNH-RA - Centre de Recherche en Nutrition Humaine Rhône-Alpes
7 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
8 Monaco Private Hemodialysis Centre
9 Hôpital Princesse Grace [Monaco]

Background and aims: Chronic inflammation plays a key role in arterial stiffness pathogenesis. Dietary components can display anti- or pro-inflammatory properties. Nonetheless, the association between the diet's overall inflammatory potential and arterial stiffness is unclear. This study aimed to assess the association between the diet's overall inflammatory potential and arterial stiffness assessed by carotid-femoral pulse wave velocity (cfPWV). Methods and results: This cross-sectional study included 1307 participants from the STANISLAS family cohort study. Dietary data were collected using a validated food frequency questionnaire. The adapted dietary inflammatory index (ADII) score was calculated to assess the inflammatory potential of the participants’ diet. The association of ADII score quartile with cfPWV was assessed using IPW-weighted linear mixed models with random family effect. The median (Q1-Q3) ADII score was 0.45 (-1.57, 2.04). Participants exhibiting higher ADII scores demonstrated elevated energy intake, dietary saturated fat, and ultra-processed foods. Conversely, individuals with lower ADII scores exhibited higher vitamins and omega intakes, and a higher diet quality, as assessed by the DASH score. Despite these observations from the descriptive analyses, ADII score quartiles were not significantly associated with cfPWV (β(95% CI) were 0.01 (-0.02,0.04) for Q2, 0.02 (-0.01,0.05) for Q3, and 0.02 (-0.01,0.05) for Q4 compared to Q1). Conclusion: In this cross-sectional study, participants had a relatively modest consumption of pro-inflammatory foods, no substantial associations were observed between the diet inflammatory potential and arterial stiffness. Further longitudinal studies in larger cohorts are needed to better understand the link between inflammatory diet and arterial stiffness.

Mots clés: ADII score; Dietary inflammatory potential; Arterial stiffness; Cardiovascular diseases

Domaines: Sciences du Vivant [q-bio]

Louis-Désiré Agbo, Nicolas Girerd, Zohra Lamiral, Kevin Duarte, Erwan Bozec, et al.. Dietary inflammatory potential and arterial stiffness in a French cohort: Insights from the STANISLAS study. Nutrition, Metabolism and Cardiovascular Diseases, 2024, ⟨10.1016/j.numecd.2024.03.022⟩. ⟨hal-04570000⟩