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Expliquer les inégalités sociales et territoriales dans l'hypertension artérielle : exploitation des cohortes française CONSTANCES et américaine HRS

Abstract : Hypertension is a leading risk factor for cardiovascular diseases. It affects nearly one out of three adults worldwide and ranks first in terms of disability-adjusted life years in women, and second in men behind smoking. However, hypertension prevalence varies between geographical regions and socioeconomic groups, and these variations are still poorly understood. Few studies have addressed these inequalities in France. In addition, little attention has been paid to social inequalities in hypertension incidence. In this context, the main objective of this thesis is to estimate and explain geographical and social inequalities in hypertension using data from two cohorts: the French CONSTANCES cohort which includes adults aged 18 to 69 years and recruited since 2012 (n=63,000) and the American HRS cohort which includes participants aged 50 and older followed since the 90s (n=17,000). This work highlights both strong geographical and socioeconomic disparities in the prevalence of hypertension in France. Marked socioeconomic inequalities also exist in the incidence of hypertension in the United States. However, behavioral and anthropometric determinants included in the analyses only partially explain the observed inequalities. Furthermore, the magnitude of inequalities and the associations between socioeconomic status, behavioral and anthropometric factors, and hypertension differ between men and women. This work provides new elements for a better identification of the most vulnerable populations and effective levers of action for prevention and reduction of inequalities in hypertension.
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Submitted on : Wednesday, May 25, 2022 - 4:54:11 PM
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Lola Neufcourt. Expliquer les inégalités sociales et territoriales dans l'hypertension artérielle : exploitation des cohortes française CONSTANCES et américaine HRS. Médecine humaine et pathologie. Université Rennes 1, 2020. Français. ⟨NNT : 2020REN1B002⟩. ⟨tel-03678982⟩

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