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Design of new molecular folded topologies and of a photoswitchable foldamer host

Abstract : Foldamer chemistry is a rapidly developing research area where scientists study the construction of various artificial architectures that inspired from the folded conformations of biopolyme rs found in nature. This thesis focuses on the design and construction of complex molecular topologies and switchable molecular motions. In the first part, with the helical disruptor strategy, variable sizes of macrocycles were built up (from 4 units to 12 units) based on quinolinecarboxamides derivatives (Q F ). Macrocycles adopted novel conformations which were totally different with the helical conformations of their own foldamer precursors. Those novel structures were confirmed by NMR and crystallographic studies. In the second part, a symmetrical helix sheet helix foldamer was prepared which has a bind with T shape rod. The photoreactions within aromatic sheets change the architectures of foldamer that cause dissociation of complex and release the rod. A thermal treatment would recover foldamer back to initial conformation and lead to the re formation of host guest complex. I n the third part, to build up the molecular Prusik knot, different turn units were incorporated with helix segments to form helix tur n helix foldamers. The conformations of helix turn helix architectures were well investigated, they adopted several kinds of conformations, such as cone shape, multiple helix and precursor of Prusik knot.
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Submitted on : Thursday, December 2, 2021 - 3:33:07 PM
Last modification on : Tuesday, January 4, 2022 - 6:16:51 AM


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  • HAL Id : tel-03463652, version 1



Chenhao Yao. Design of new molecular folded topologies and of a photoswitchable foldamer host. Organic chemistry. Université de Bordeaux, 2021. English. ⟨NNT : 2021BORD0270⟩. ⟨tel-03463652⟩



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