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Étude des propriétés fonctionnelles d’une population d’interneurones GABAergiques inhibiteurs du néocortex

Abstract : The aim of this work was to carry out a functional study of a population of neocortical GABAergic interneurons. The combination of electrophysiological, molecular biology and histochemical techniques enabled us to demonstrate that interneurons sensitive to nicotinic agonists expressing vasoactive intestinal peptide and cholecystokinin can be synaptically activated by afferent serotonergic fibers originating from the raphé nucleus via the type 3 serotonergic receptor. Evidence of the selective expression of the μ-opioid receptor together with preproenkephalin in this neuronal population led us to demonstrate the existence of an enkephalinergic autoregulatory loop specific to these interneurons. The identification of such mechanisms controlling the activity of a neuronal population enables us to propose a specific role for these interneurons in the physiology of the neocortical network.
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https://hal.archives-ouvertes.fr/tel-03322180
Contributor : Isabelle Ferezou Connect in order to contact the contributor
Submitted on : Wednesday, August 18, 2021 - 4:54:39 PM
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Isabelle Ferezou. Étude des propriétés fonctionnelles d’une population d’interneurones GABAergiques inhibiteurs du néocortex. Neurobiologie. Université Paris VI, 2003. Français. ⟨tel-03322180⟩

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