, Ci-dessous les étapes suivies pour le marquage par immunofluorescent du collagène de type IV (Anti-collagène et anti-IgG) : 1-Lavage avec du PBS (0.01 M
, -Trempage pendant 12h à une température de 4° dans une solution de PBS-Tween (0.01%), du BSA (1%) et d'anticorps anti-collagène IV
, Lavage avec du PBS
, Marquage avec l'anticorps secondaire anti-IgG conjugué avec de la fluorescéine
, La mesure moyenne du TBVf à chaque stade tumoral et pour chaque groupe est présentée dans la figure IV.17. Entre J9 et J12, le TBVf a augmenté de façon significative
, Le TBVf a diminué significativement dans le groupe traité quatre jours après l'injection de Bevacizumab
, Aucun changement statistiquement significatif n'a été observé dans le groupe non traité entre J12 et J16
, Histogramme du TBVf pour les groupes de souris traitées et non traitées à différents stades de progression tumorale. Les changements significatifs de TBVf sont marqués par des astérisques « *, vol.17
, 01 s -1 et 0,05 ± 0,03 s -1 ), mais le changement n'était pas statistiquement significatif. De même, Concernant le suivi de K model (figure IV.18), nous avons trouvé que ce paramètre avait tendance à augmenter entre J9 et J12 (0,025 ± 0
Rapid -Steady -State -T 1 signal modeling during contrast agent extravasation: towards tumor blood volume quantification without requiring the arterial input function, Magnetic Resonance in Medicine, 2015. ,
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Tumor blood volume quantification by RSST 1 -MRI method despite contrast agent leakage and without arterial input function determination ,
Pharmacokinetic model for fractional blood volume quantification with the Rapid Steady State T 1 MRI technique in tumors ,
, Glioblastoma pH mapping by using Yb-HPDO3A CEST MRI probe. EMIM-2016, Ultrech Pays Bas
Volumetric quality assurance of RapidArc plans for multiple intracranial targets using gel dosimetry, 2016. ,
Monitoring quantitative tumor blood volume in mouse brain under Bevacizumab by the RSST 1 -MRI method ,
RSST 1 -MRI method for monitoring quantitative tumor blood volume and vessel permeability in humain glioblastoma implented in mouse brain under Bevacizumab ,
,
, Sensibilité de la méthode RSST 1 aux variations quantitatives de l'angiogenèse tumorale: suivi de croissance du gliome U87 chez la souris et effet du Bevacizumab. SFRMBM-2015
Novel pharmacokinetic model for fractional blood volume quantification with the Rapid Steady State T 1 MRI technique in tumors with Gd-DOTA permeable vasculature ,
,
, En pratique et pour une même dose à injecter (0,7mmol/kg), il a été préférable d'injecter un grand volume de Gd-DOTA à faible concentration
, Chez le rat l'administration d'un agent de contraste par voie intraveineuse est moins délicate que chez la souris car le volume total injectable est plus grand
, Le prolongateur utilisé est modifié, le tube PE 10 est remplacé par un tube PE 20 (diamètre interne de 0,38 mm). La seringue d'insuline est remplacée par une seringue sans aiguille (1ml)
, La méthode RSST 1 est appliquée quelques secondes après injection du Gd-DOTA en i.v et pendant une courte durée, de l'ordre d'une minute. La méthode RSST 1 se base sur une injection du Gd-DOTA à forte concentration. 1-Hypothèse 1 : Clairance très faible donc n'est pas pris en compte. 2-Hypothèse 2 : L'échange de l'AC est mené uniquement par l
, Le signal vasculaire est supposé à son maximum et constant pendant la courte durée d'analyse du signal RSST 1 mais la concentration plasmatique est très élevée mais décroît uniquement vers le compartiment extravasculaire, vol.3, 2016.
, Métrologie des faisceaux de traitement TRS 398 & 277, 2017.
, Mise en place et application d'un système d'audit de qualité pour la délivrance de dose en radiothérapie et le suivie du patient, pp.2017-2018
, Mise en place du système de contrôle de qualité, pp.2017-2018
, Lister et organiser les tests de contrôle de qualité des accélérateurs linéaires ainsi qu'optimiser le temps de la realisation de ces contrôles, 2016.
, Contrôle de qualité des appareils de traitement et de diagnostic (i.e. CLINAC & SYNERGY, CT-Scan, IRM, TEP, SPECT, pp.2015-2017
, Mise en place et application du protocole d'assurance qualité "3D end-to-end" en Radiochirurgie par modulation d'intensité des multiples lésions cérébrales, 2015.
,
, , pp.2015-2018
, Contrôle de qualité des faisceaux du plan de traitement des patients, 2009.
, Mise en place des séquences d'imagerie IRM (i.e. RSST 1
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