, Et pour conclure, mes frères, je citerai Saint Jean, dans son Epître aux Chercheurs, Livre LXXIII, vol.8, pp.2-3
, Et le 15 éme jour, épuisé par une dure semaine
, Se demandant quelle utilité cette protéine pourrait bien avoir dans son
elle s'auto-associait. Stupéfait d'horreur et devinant un méfait du Malin, il décida d'enfouir la protéine diabolique au plus profond du plus épais des animaux : le pancréas du bovin, là où les Hommes ne pourraient jamais l'atteindre. Rasséréné, il décida alors de s'accorder un jour de congé supplémentaire, J. Cryst. Growth, vol.235, pp.547-554, 2002. ,
, Nucl. Instrum. Methods A, vol.249, pp.399-407, 1986.
, LURE: rapport d'activité pour la période Août, 1985.
, J. Appl. Cryst, vol.30, pp.49-54, 1997.
, Proc. Natl Acad. Sci USA, vol.97, pp.6277-6281, 2000.
, J. Cryst. Growth, vol.196, pp.388-394, 1999.
, Acta Cryst, vol.55, pp.103-113, 1999.
, , 2000.
, J. Mol. Biol, vol.297, pp.697-712, 2000.
, J. Cryst. Growth, vol.173, pp.132-140, 1997.
, Ann. Rev. Biophys. Bioeng, vol.9, pp.1-29, 1980.
, J. Chem. Phys, vol.107, pp.1953-1961, 1997.
, J. Appl. Cryst, vol.28, pp.768-773, 1995.
Neutron and synchrotron radiation for condensed matter studies, vol.III, pp.145-160, 1994. ,
, Acta Cryst, vol.50, pp.355-360, 1979.
, Science, vol.277, pp.1975-1978, 1997.
Moleculargewicht, endgruppenanalyse, und aminosaure-zusammensetzung, Strukturuntersuchungen am kallikrein-inaktivator aus rinderlunge I, pp.457-462, 1965. ,
The disulfide linkages in kallikrein inactivator of bovine lung, The J. of Biological Chemistry, vol.241, issue.7, pp.1568-1572, 1965. ,
theory of protein solubility, Methods in enzymology, vol.114, pp.49-77, 1985. ,
Oligomerization and phase separation in globular protein solutions, Biophysical Chemistry, vol.75, pp.213-227, 1998. ,
a-amylase crystal growth investigated by in situ atomic force microscopy, J. Cryst. Growth, vol.226, pp.294-302, 2001. ,
Systematic studies on the crystallization of lysozyme, J. Cryst. Growth, vol.90, pp.86-93, 1988. ,
Electrostatic interactions in colloidal solutions: comparison between primitive and one-component models, J. Chem. Phys, vol.85, issue.1, pp.519-526, 1986. ,
Self-consistent integral equation applied to the highly charged primitive model, J. Chem. Phys, vol.88, issue.8, pp.5143-5148, 1988. ,
Interacting monodisperse and polydisperse spheres. Neutron, X-Ray and light scattering, D. Series. Amsterdam, pp.135-155, 1991. ,
Diffusion de la lumière, 1994. ,
Strong and specific effects of cations on lysozyme chloride solubility, Acta Cryst. D, vol.58, pp.1582-1587, 2002. ,
Dynamic light scattering with applications to chemistry, biology, and physics, 1976. ,
Concepts de la cristallisation en solution. Actualités néphrologiques, Flamarion medecine sciences, pp.159-202, 1985. ,
Crystallization mechanisms in solution, J. Cryst. Growth, vol.90, pp.14-30, 1988. ,
, , 1992.
phase transition, kinetic ripening and growth rates of porcine pancreatic a-amylase isoenzymes, J. Crystal Growth, vol.123, pp.109-120 ,
Protein crystallization:contribution of small angle X ray scattering, Journal de Physique IV, vol.118, pp.3-13, 2004. ,
Second virial coefficient: variations with lysozyme crystallization conditions, Journal of Crystal Growth, vol.196, issue.2-4, pp.403-414, 1999. ,
Specific ion effects: Why DLVO theory fails for biology and colloid systems, Phys. Rev. Lett, vol.87, issue.16, pp.168103-168104, 2001. ,
Binaryliquid phase separation of lens protein solutions, Proc. Natl. Acad. Sci. USA, vol.88, pp.5660-5664, 1991. ,
Using phase transitions to investigate the effect of salts on protein interactions, Physical Review. E. Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, vol.53, issue.6, pp.6325-6335, 1996. ,
Cristallisation et caractérisation de protéines en solution : diagrammes de phases, cinétiques de croissance et associations moléculaires, 1998. ,
The Hoffmeister series: salt and solvent effects on interfacial phenomena, Q. Rev. Biophys, vol.30, pp.241-277, 1997. ,
Free energy of a nonuniform system. III. Nucleation in a two-component incompressible fluid, The Journal of chemical physics, vol.31, issue.3, pp.688-699, 1959. ,
The Hoffmeister effect and the behaviour of water at interfaces, Q. Rev. Biophys, vol.18, issue.4, pp.323-422, 1985. ,
The unit cells of four proteins, Acta Crystallogr, vol.6, pp.221-222, 1953. ,
, , 2002.
, Protein-protein interactions in concentrated electrolyte solutions, Biotechnol. Bioeng, vol.79, issue.4, pp.367-380
Effect of calcium on the calf lens cytoplasm, Exp Eye Res, vol.44, issue.5, pp.601-617, 1987. ,
Short-range order of crystallin proteins accounts for eye lens transparency, Nature, vol.302, issue.31, pp.415-417, 1983. ,
,
LURE: rapport d'activité pour la période Aout, 1985. ,
Crystallographc refinement of the the structure of bovine pancreatic trypsin inhibitor at 1.5 A resolution, Acta. Cryst. B, vol.31, pp.238-250, 1975. ,
Improved signal-to-background ratio in small angle X-ray scattering experiments with synchrotron radiation using an evacuated cell for solutions, J. Appl. Cryst, vol.30, pp.49-54, 1997. ,
Crystallization of nucleic acidsand protéins -a practical approach, 1992. ,
Solubilisation, solubilité, diagrammes de phase: application à la cristallisation des proteines, Les cahiers Imabio, vol.15, 1995. ,
Protein-solvent and weak protein-protein interactions in halophilic malate dehydrogenase, J. Cryst. Growth, vol.196, issue.2-4, pp.395-402, 1999. ,
Protein Data Bank entry 9PTI, Brookhaven National Laboratory, 1991. ,
Effect of glycerol on the interactions and solubility of BPTI, Biophysical Journal, vol.76, pp.2716-2726, 1999. ,
Lysozyme crystal growth, as observed by small angle X-ray scattering, proceeds without crystallization intermediates, EUR. BIOPHYS. J, vol.27, pp.263-271, 1998. ,
Liquid-Liquid separation in solutions of normal and sickle cell hemoglobin, PNAS, vol.99, issue.13, pp.8479-8483, 2002. ,
Direct determination of the nucleation rates of protein crystals, J. Phys. Chem. B, vol.103, pp.10965-10971, 1999. ,
Control of protein crystal nucleation around the metastable liquid-liquid phase boundary, PNAS, vol.97, issue.12, pp.6277-6281, 2000. ,
Are nucleation kinetics of protein crystals similar to those of liquid droplets?, J. Am. Chem. Soc, vol.122, pp.156-163, 2000. ,
Nucleation of protein crystals: critical nuclei, phase behavior, and control pathways, J. Cryst. Growth, vol.232, pp.63-76, 2001. ,
The concentration dependence of the diffusion coefficient for BPTI: a dynamic light scattering study of a small protein, Biopolymers, vol.28, pp.2001-2024, 1989. ,
Agarose as crystallization media for proteins I: Transport processes, J. Cryst. Growth, vol.232, pp.165-172, 2001. ,
Dynamics and microstructure formation during nucleation of lysozyme solutions, J. Am. Chem. Soc, vol.120, pp.5539-5548, 1998. ,
Formation dynamics of protein precrystallization fractal clusters, J. Cryst. Growth, vol.126, pp.245-260, 1993. ,
Predicting protein crystallisation from a dilute solution property, Acta Cryst. D, vol.50, pp.361-365, 1994. ,
Protein self association in solution: The BPTI decamer, Biophysical Journal, vol.84, pp.3941-3958, 2003. ,
VIII. The solubility of hemoglobin in concentraed salt solutions. A study of the salting out of proteins, Studies in the physical chemistry of the proteins, pp.495-516, 1931. ,
X. The solubility of hemoglobin in solutions of chlorides and sulfates of varying concentration, Studies in the physical chemistry of the proteins, pp.47-66, 1932. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00025132
Small-angle neutron scattering study of a world-wide known emilsion: le Pastis, Colloids and surfaces A: Physicochem. Eng. Aspects, vol.225, pp.153-160, 2003. ,
BPTI liquid-Liquid phase separation monitored by light and small angle X-ray scattering, Acta Cryst. D, vol.58, pp.1560-1563, 2002. ,
Thermodynamics. An advanced treatment for chemists and physicists, 1959. ,
Spatial reorganization of lowmolecular-weight proteins during cold cataract opacification, Biochim Biophys Acta, vol.800, issue.1, pp.28-32, 1955. ,
Understanding protein crystallisation on the basis of the phase diagram, J. Cryst. Growth, vol.196, pp.388-394, 1999. ,
Cristallogenèse du BPTI à pH acide: étude des relations entre l'état d'association des molécules en solution et à l'état cristallin par diffusion et diffraction des rayons X, 2000. ,
,
The BPTI decamer observed in acidic pH crystal forms pre-exists as a stable species in solution, J. Mol. Biol, vol.297, pp.697-712, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-01745681
The decameric structure of BPTI crystallized from thiocyanate at 2.7 A resolution, Acta Cryst. D, vol.55, pp.103-113, 1999. ,
URL : https://hal.archives-ouvertes.fr/hal-01745648
, Phase equilibria, phase diagrams and phase transfomations, 1998.
Zur lehre von der wirkung der salze, Arch. Exp. Pathol. Pharmakol, vol.24, pp.247-260, 1888. ,
The solubility of hen eggwhite lysozyme, J. Cryst. Growth, vol.90, pp.94-104, 1988. ,
The basic trypsin inhibitor of bovine pancreas, Naturwissenschaften, vol.57, pp.389-392, 1970. ,
A pulsed field gradient NMR study of BPTI self association, Biochemistry, vol.36, pp.3383-3388, 1997. ,
Critical behavior of a binary mixture of protein and salt water, Phys. Rev. Lett, vol.39, issue.8, pp.474-477, 1977. ,
Intermolecular and surface forces, 1994. ,
Role of hydratation and waterstructure in biological and colloidal interactions, Nature, vol.379, pp.219-225, 1996. ,
Intermolecular and surface forces, with applications to colloidal and biological systems, 1985. ,
The basic trypsin inhibitor of bovine pancreas V. the disulfide linkages, Biochemical and biophysical reaserch communications, vol.20, issue.4, pp.463-468, 1965. ,
Uber die inaktivierung des kallikreins, Hoppe Seylers Z. Physiol. Chem, vol.192, pp.1-21, 1930. ,
Versuche zur isolierung des kallikreininaktivators, III. Elektrophoretische reinung und molekulargewichts-bestimmung in der ultrazentrifuge, Hoppe Seylers Z. Physiol. Chem, vol.321, pp.90-96, 1960. ,
Isolation from beef pancreas of crystalline trypsinogen, tripsin, a trypsin inhibitor and a inhibitor-trypsin compound, J. Gen. Physiol, vol.19, pp.991-1007, 1936. ,
The liquid protein phase in crystallization : a case study-intact immunoglobulins, J. Crystal Growth, vol.232, pp.30-39, 2001. ,
Study of liquid-liquid demixing from drug solution, J. Cryst. Growth, vol.269, pp.550-557, 2004. ,
Interactions des molécules de protéines en solution, application à la cristallogenèse, 1996. ,
Solubility and prenucleation of aprotinin (BPTI) molecules in sodium chloride solutions, J. Crystal Growth, vol.14, pp.249-255, 1994. ,
Prenucleation and crystallisation of proteins : Application to BPTI Solutions, 1996. ,
Comparison of solubilities and molecular interactions of BPTI molecules giving different polymorphs, J. Crystal Growth, vol.173, pp.132-140, 1997. ,
,
Phase behaviour of colloid+polymer mixtures, Europhysics letters, vol.20, issue.6, pp.559-564, 1992. ,
Neutron, X-ray and light scattering: introduction to an investigative tool for colloidal and polymeric systems, 1991. ,
Chemical thermodynamics of materials, 1983. ,
Charge stabilized liquidlike ordered binary colloidal suspensions. 1. Ultra-Small-Angle X-Ray scattering characterization, Langmuir, vol.15, pp.337-344, 1999. ,
, , 1999.
, Charge stabilized liquidlike ordered binary colloidal suspensions. 2. Partial structure factors determined by small-angle neutron scattering, Langmuir, vol.15, pp.345-352
A model of attractive interactions to account for fluid-fluid phase separation of protein solutions, J. Chem. Phys, vol.105, issue.8, pp.3290-3300, 1996. ,
Crystallisation of satellite tobacco mosaic virus I. Nucleation phenomena, J. Cryst. Growth, vol.126, pp.544-554, 1993. ,
Light scattering investigation of protein and virus crystal growth: ferritin, apoferritin and satellite tobacco mosaic virus, J. Cryst. Growth, vol.128, pp.1232-1235, 1993. ,
Crystallisation of satellite tobacco mosaic virus II. Postnucleation events, J. Cryst. Growth, vol.126, pp.555-564, 1993. ,
Light scattering investigation of nucleation processes and kinetics of crystallization in macrmolecular systems, Acta Cryst. D, vol.50, pp.385-395, 1994. ,
Hydratation in electrical double layers, Nature, vol.38, pp.689-690, 1997. ,
Atomic force microscopy in the study of macromolecular crystal growth, Annu. Rev. Biophys. Biomol. Struct, vol.29, pp.361-410, 2000. ,
Salt effect on hydrophobic interactions in precipitation and chromatography of proteins: an interpretation of the lyotropic series, Arch. Biochem. Biophys, vol.183, issue.1, pp.200-215, 1977. ,
BPTI as unusual thermodynamic stability parameters, J. Mol. Biol, vol.170, pp.765-776, 1983. ,
L-L phase separation in supersaturated lysozyme solutions and associated precipitate formation/crystallisation, J. Chem. Phys, vol.107, issue.6, pp.1953-1961, 1997. ,
Interfacial tensions electrolyte crystal-aqueous solution from nucleation data, J. Cryst. Growth, vol.11, pp.233-242, 1971. ,
Small angle neutron scattering from lysozyme in unsaturated solutions, to characterize the pre-crystallization process, J. Cryst. Growth, pp.671-675, 1994. ,
, Crystalline Enzymes, 1948.
Studien uber die bildung und umwandlung fester korper, Z Physik Chem, vol.22, pp.289-330, 1897. ,
, Statistical Mecanics, pp.405-407, 1996.
Pore size of agarose gels by atomic force microscopy, Electrophoresis, vol.18, pp.55-58, 1997. ,
Liquid-liquid phase separation of a surfactantsolubilized membrane protein, PRL, vol.90, issue.20, pp.208101-208102, 2003. ,
Numerical recipes -The art of scientific computing, 1986. ,
Stability of proteins -smal globular proteins, Advances in protein chemistry, vol.33, pp.167-241, 1979. ,
, , 2005.
, Lysozyme cristallization rates controlled by anomalous fluctuations, J. Cryst . Growth, vol.274, pp.536-544
A method for rapid liquid-solid phase solubility measurements using the protein lysozyme, J. Cryst. Growth, vol.88, pp.419-424, 1988. ,
Estimation of the initial equilibrium constants in the formation of tetragonal lysozyme nuclei, J. Cryst. Growth, vol.110, pp.60-65, 1991. ,
Relative effectiveness of various ions on the solubility and crystal growth of lysozyme, J. Biol. Chem, vol.264, issue.2, pp.745-753, 1989. ,
From solutions to crystals with a physicochemical aspect, 1999. ,
Van der Waals interactions betwenn proteins, Biophys. J, vol.70, pp.977-987, 1996. ,
, Die makromolekulare chemie, vol.98, pp.204-234, 1966.
Introduction to phase transitions and critical phenomena, p.42, 1971. ,
Equilibrium cluster formation in concentrated protein solutions and colloids, Nature, vol.432, pp.492-495, 2004. ,
CRYSOL -a program to evaluate X ray solution scattering of biological macromolecules from atomic coordinates, J. Appl. Cryst, vol.28, pp.768-773, 1995. ,
, , 1998.
, Protein hydration in solution: experimental observation by X-ray and neutron scattering, Proc. Natl. Acad. Sci, vol.95, pp.2267-2272
Crystal nucleation in the presence of a metastable critical point, J. Chem. Phys, vol.109, issue.1, pp.223-227, 1998. ,
PH-dependent oligomerisation of BPTI in undersaturated ans supersaturated solutions studied by DLS, J. Crystal Growth, vol.237, pp.289-294, 2002. ,
Physical Chemistry of Macromolecules, 1961. ,
Liquid-Liquid phase separation of aqueous lysozyme solutions: Effect of pH and salt identity, J. Phys. Chem, vol.94, pp.2140-2144, 1990. ,
Thermodynamics and structure -concentrated solutions -structured disorder in vision, pp.146-154, 1994. ,
Proteins in solution : from X-ray scattering intensities to interaction potentials, J. Cryst . Growth, vol.196, pp.196-203, 1999. ,
Protein interactions in the calf eye lens : interactions between b-crystallins are repulsive whereas in g-crystallins they are attractive, Eur. Biophys. J, vol.21, pp.1-12, 1992. ,
, , 1987.
, Binary liquid phase separation and critical phenomena in a protein/water solution, Proc. Natl. Acad. Sci, vol.84, pp.7079-7083
Mechanism of protein precipitation and stabilisation by co-solvents, J. Cryst. Growth, vol.90, pp.39-46, 1988. ,
Properties of the protein solvent interface, studied by deuterium exchange in basic pancreatic trypsin inhibitor, Protides Biol. Fluids, vol.35, pp.437-448, 1987. ,
Small angle X-Ray scattering by solutions of biological macromolecules. International school of physics, Enrico Fermi" Course CXXVIII, 1996. ,
Temperature and pH effect on the polymorphism of aprotinin (BPTI) in sodium bromide solutions, Crystal growth & design, vol.4, issue.6, pp.1137-1141, 2004. ,
Prenucleation, crystal growth and polymorphism of some proteins, J. Cryst. Growth, vol.168, pp.124-129, 1996. ,
Dense liquid precursor for the nucleation of ordered solid phases from solution, Crystal growth & design, vol.4, pp.671-685, 2004. ,
Growth processes of protein crystals revealed by laser michelson interferometry investigation, Acta Cryst. D, vol.51, pp.207-219, 1995. ,
, Numerical recipes -example book (Fortran), 1986.
Cristallogenèse d'un lysozyme en gel d'agarose et en gel de silice. Sciences de la matière, 1997. ,
Liquid droplet dispersions formed by homogeneous liquidliquid nucleation: "the Ouzo effect, Langmuir, vol.19, pp.4105-4110, 2003. ,
Interactions en solution et cristallisation de l'urate oxydase, 2003. ,
Catching the PEG-induced attractive interaction between proteins, Eur. Phys. J. E, vol.9, pp.15-25, 2002. ,
X-Ray scattering studies of Aspergillus flavus urate oxidase: towards a better understanding of PEG effects on the crystallization of large proteins, Acta Cryst. D, vol.58, pp.472-479, 2002. ,
Liquid-liquid phase separation in urate oxidase/PEG mixtures: characterization and implications for protein crystallization, J. Phys. Chem. B, vol.108, pp.6498-6507, 2004. ,
Quantitative imaging by confocal scanning fluorescence microscopy of protein crystallization via liquid-liquid phase separation, Acta Cryst. D, vol.61, pp.819-825, 2005. ,
Pancreatic Tripsin Inhibitor, J. Mol. Biol, vol.167, pp.911-917, 1983. ,
Concentration dependence of the diffusion coefficient of a dimerizing protein: BPTI, J. Phys. Chem, vol.85, pp.3978-3984, 1981. ,
Comparison of two higly refined structures of BPTI, J. Mol. Biol, vol.193, pp.145-156, 1987. ,
Structure of form III crystals of BPTI, J. Mol. Biol, vol.198, pp.469-480, 1987. ,
Enhancement of protein crystal nucleation by critical density fluctuations, Science, vol.277, 1997. ,
,
Depletion interactions in colloid-polymer mixtures, Phys. Rev. E, vol.54, issue.6, pp.6500-6510, 1996. ,
Self-association of BPTI: specific or nonspecific?, Biopolymers, vol.31, pp.1347-1349, 1991. ,
,