Analyse et gestion des mouvements physiologiques en IRM thoraco-abdominale

Abstract : Magnetic Resonance Imaging (MRI) has become a major medical Imaging technique thanks to high temporal and spatial resolution, as well as to its abilities to distinguish between tissues. On one hand, MRI examinations of thoracic and abdomino-pelvic organs are compromised by the motions induced by circulation and respiration, but on the other hand, MRI is a non-invasive and precise tool to study these displacements. We have shown, in a group of patients with cystic fibrosis (CF), that the diaphragmatic course was around 1 to 2cm, as it is in normal subjects. In another study, we have found that motions of the kidney was in the same range in infants and in adults, despite the difference in the size of this organ; this is a major cause of error when performing functional analysis. Managing these motions is based upon breath holding and synchronization, both remaining imperfect. Thus, we showed how an in-lab dual synchronization, both cardiac and respiratory, improved quality of lung images in the patients with CF, and how we managed realizing high quality cardiac cine-MRI using the GRICS algorithm. At last, we discuss the specific difficulties of kinetic imaging of contrast agents through a few studies, and explain the bases of an efficient registration method.
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Damien Mandry. Analyse et gestion des mouvements physiologiques en IRM thoraco-abdominale. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2009. Français. ⟨NNT : 2009NAN10096⟩. ⟨tel-01748352⟩

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