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A. Partir-d, ADNc codant pour eEF-1?, nous avons obtenu un anticorps spécifique Il nous a permis de montrer que la protéine eEF-1? existe, dans l'ovule d'oursin, sous deux isoformes présentes dans un complexe de haut poids moléculaire et que eEF-1? est fortement associée à eEF-1?. Des protéines présentant des homologies avec une protéine chaperon et une protéine ribosomale restent associées à eEF

. Un-messager-synthétique, sans initiation spécifique, a été traduit dans des lysats de réticulocytes de lapin pour comprendre le rôle de l'association de la Val-RS au complexe Selon le site de fixation du ribosome, il conduit à un peptide polyValine ou polySérine, La traduction du polyValine est toujours supérieure à celle du polySérine. La phosphorylation avec CDK1/cycline B diminue l'élongation du polyValine et augmente celle du polySérine