A. Abrieu, T. Brassac, S. Galas, D. Fisher, J. C. Labbe et al., The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs, J Cell Sci, vol.111, pp.1751-1757, 1998.

J. F. Acquavella, B. H. Alexander, J. S. Mandel, C. Gustin, B. Baker et al., Glyphosate Biomonitoring for Farmers and Their Families: Results from the Farm Family Exposure Study, Environmental Health Perspectives, vol.112, issue.3, pp.321-326, 2004.
DOI : 10.1289/ehp.6667

A. Adam, A. Marzuki, A. Rahman, H. Aziz, and M. , The oral and intratracheal toxicities of ROUNDUP and its components to rats, Vet Hum Toxicol, vol.39, pp.147-151, 1997.

M. C. Alavanja, J. A. Hoppin, and F. Kamel, Health Effects of Chronic Pesticide Exposure: Cancer and Neurotoxicity, Annual Review of Public Health, vol.25, issue.1, pp.155-197, 2004.
DOI : 10.1146/annurev.publhealth.25.101802.123020

M. F. Alibhai and W. C. Stallings, Closing down on glyphosate inhibition--with a new structure for drug discovery, Proceedings of the National Academy of Sciences, vol.98, issue.6, pp.2944-2946, 2001.
DOI : 10.1073/pnas.061025898

A. Amon, The spindle checkpoint, Current Opinion in Genetics & Development, vol.9, issue.1, pp.69-75, 1999.
DOI : 10.1016/S0959-437X(99)80010-0

T. E. Arbuckle, Z. Lin, and L. S. Mery, An Exploratory Analysis of the Effect of Pesticide Exposure on the Risk of Spontaneous Abortion in an Ontario Farm Population, Environmental Health Perspectives, vol.109, issue.8, 2001.
DOI : 10.1289/ehp.01109851

D. Arion and L. Meijer, M-phase-specific protein kinase from mitotic sea urchin eggs: Cyclic activation depends on protein synthesis and phosphorylation but does not require DNA or RNA synthesis, Experimental Cell Research, vol.183, issue.2, pp.361-375, 1989.
DOI : 10.1016/0014-4827(89)90397-2

D. Arion, L. Meijer, L. Brizuela, and D. Beach, cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF, Cell, vol.55, issue.2, pp.371-378, 1988.
DOI : 10.1016/0092-8674(88)90060-8

J. C. Axelrad, C. V. Howard, and W. G. Mclean, The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon, Toxicology, vol.185, issue.1-2, pp.67-78, 2003.
DOI : 10.1016/S0300-483X(02)00592-9

D. B. Barr, J. R. Barr, W. J. Driskell, R. H. Hill, . Jr et al., Strategies for biological monitoring of exposure for contemporary-use pesticides, Toxicology and Industrial Health, vol.15, issue.1, pp.168-179, 1999.
DOI : 10.1191/074823399678846556

D. B. Barr and L. L. Needham, Analytical methods for biological monitoring of exposure to pesticides: a review, Journal of Chromatography B, vol.778, issue.1-2, pp.5-29, 2002.
DOI : 10.1016/S1570-0232(02)00035-1

J. Bartek and J. Lukas, Mammalian G1- and S-phase checkpoints in response to DNA damage, Current Opinion in Cell Biology, vol.13, issue.6, pp.738-747, 2001.
DOI : 10.1016/S0955-0674(00)00280-5

C. R. Bartholomew, S. H. Woo, Y. S. Chung, C. Jones, and C. F. Hardy, Cdc5 Interacts with the Wee1 Kinase in Budding Yeast, Molecular and Cellular Biology, vol.21, issue.15, pp.4949-4959, 2001.
DOI : 10.1128/MCB.21.15.4949-4959.2001

M. Belles, M. L. Albina, D. J. Sanchez, J. Corbella, and J. L. Domingo, Interactions in developmental toxicology: effects of concurrent exposure to lead, organic mercury, and arsenic in pregnant mice, Arch Environ Contam Toxicol, vol.42, pp.93-98, 2002.

R. Bharadwaj and H. Yu, The spindle checkpoint, aneuploidy, and cancer, Oncogene, vol.23, issue.11, pp.2016-2027, 2004.
DOI : 10.1038/sj.onc.1207374

L. G. Blackburn and C. Boutin, Subtle effects of herbicide use in the context of genetically modified crops: a case study with glyphosate (Roundup), Ecotoxicology, vol.12, issue.1/4, pp.271-285, 2003.
DOI : 10.1023/A:1022515129526

A. Blasina, I. V. De-weyer, M. C. Laus, W. H. Luyten, A. E. Parker et al., A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase, Current Biology, vol.9, issue.1, pp.1-10, 1999.
DOI : 10.1016/S0960-9822(99)80041-4

C. Bolognesi, Genotoxicity of pesticides: a review of human biomonitoring studies, Mutation Research/Reviews in Mutation Research, vol.543, issue.3, pp.251-272, 2003.
DOI : 10.1016/S1383-5742(03)00015-2

A. Borgne, A. C. Ostvold, S. Flament, and L. Meijer, Intra-M Phase-promoting Factor Phosphorylation of Cyclin B at the Prophase/Metaphase Transition, Journal of Biological Chemistry, vol.274, issue.17, pp.11977-11986, 1999.
DOI : 10.1074/jbc.274.17.11977

J. W. Brandis and R. A. Raff, Translation of oogenetic mRNA in sea urchin eggs and early embryos, Developmental Biology, vol.67, issue.1, pp.99-113, 1978.
DOI : 10.1016/0012-1606(78)90303-2

J. W. Brandis and R. A. Raff, Elevation of protein synthesis is a complex response to fertilisation, Nature, vol.67, issue.5703, pp.467-469, 1979.
DOI : 10.1038/273536a0

R. L. Brent, Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents), Pediatrics, vol.113, pp.984-995, 2004.

D. W. Brewster, J. Warren, and W. E. Hopkins, Metabolism of glyphosate in Sprague-Dawley rats: Tissue distribution, identification, and quantitation of glyphosate-derived materials following a single oral dose*1, Fundamental and Applied Toxicology, vol.17, issue.1, pp.43-51, 1991.
DOI : 10.1016/0272-0590(91)90237-X

D. V. Bulavin, Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur et al., Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase, Nature, vol.411, issue.6833, pp.102-107, 2001.
DOI : 10.1038/35075107

F. Bunz, A. Dutriaux, C. Lengauer, T. Waldman, S. Zhou et al., Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage, Science, vol.282, issue.5393, pp.1497-1501, 1998.
DOI : 10.1126/science.282.5393.1497

J. K. Buolamwini, Cell Cycle Molecular Targets in Novel Anticancer Drug Discovery, Current Pharmaceutical Design, vol.6, issue.4, pp.379-392, 2000.
DOI : 10.2174/1381612003400948

L. Busino, M. Chiesa, G. F. Draetta, and M. Donzelli, Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis, Oncogene, vol.23, issue.11, pp.2050-2056, 2004.
DOI : 10.1038/sj.onc.1207394

C. V. Cabrera, J. J. Lee, J. W. Ellison, R. J. Britten, and E. H. Davidson, Regulation of cytoplasmic mRNA prevalence in sea urchin embryos, Journal of Molecular Biology, vol.174, issue.1, pp.85-111, 1984.
DOI : 10.1016/0022-2836(84)90366-8

D. J. Carroll, D. T. Albay, M. Terasaki, L. A. Jaffe, and K. R. Foltz, Identification of PLCgamma-dependent and -independent events during fertilization of sea urchin eggs, 1999.

P. Chan and J. Mahler, NTP technical report on the toxicity studies of Glyphosate (CAS No. 1071-83-6) Administered In Dosed Feed To F344/N Rats And B6C3F1 Mice, Toxic Rep Ser, vol.16, pp.1-3, 1992.

J. P. Chow, W. Y. Siu, H. T. Ho, K. H. Ma, C. C. Ho et al., Differential Contribution of Inhibitory Phosphorylation of CDC2 and CDK2 for Unperturbed Cell Cycle Control and DNA Integrity Checkpoints, Journal of Biological Chemistry, vol.278, issue.42, pp.40815-40828, 2003.
DOI : 10.1074/jbc.M306683200

P. R. Clarke, I. Hoffmann, G. Draetta, and E. Karsenti, Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts., Molecular Biology of the Cell, vol.4, issue.4, pp.397-411, 1993.
DOI : 10.1091/mbc.4.4.397

T. R. Coleman, Z. Tang, and W. G. Dunphy, Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer, Cell, vol.72, issue.6, pp.919-929, 1993.
DOI : 10.1016/0092-8674(93)90580-J

P. Collas, Formation of the sea urchin male pronucleus in cell-free extracts, Molecular Reproduction and Development, vol.12, issue.S2, pp.265-270, 2000.
DOI : 10.1002/(SICI)1098-2795(200006)56:2+<265::AID-MRD11>3.0.CO;2-P

C. Colosio, M. Tiramani, and M. Maroni, Neurobehavioral Effects of Pesticides: State of the Art, NeuroToxicology, vol.24, issue.4-5, pp.577-591, 2003.
DOI : 10.1016/S0161-813X(03)00055-X

D. W. Connell, Basic concepts of Envrionmental Chemistry, 1997.

M. Costa, Carcinogenic metals, Sci Prog, vol.81, pp.329-339, 1998.

S. N. Dalal, C. M. Schweitzer, J. Gan, and J. A. Decaprio, Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site, Molecular and Cellular Biology, vol.19, issue.6, pp.4465-4479, 1999.
DOI : 10.1128/MCB.19.6.4465

E. Dallegrave, F. D. Mantese, R. S. Coelho, J. D. Pereira, P. R. Dalsenter et al., The teratogenic potential of the herbicide glyphosate-Roundup?? in Wistar rats, Toxicology Letters, vol.142, issue.1-2, 2003.
DOI : 10.1016/S0378-4274(02)00483-6

J. Daruich, F. Zirulnik, and M. S. Gimenez, Effect of the Herbicide Glyphosate on Enzymatic Activity in Pregnant Rats and Their Fetuses, Environmental Research, vol.85, issue.3, pp.226-331, 2001.
DOI : 10.1006/enrs.2000.4229

E. H. Davidson, The nature and function of maternal transcriptsGene activity in early development, pp.46-125, 1986.

D. Bondt, H. L. Rosenblatt, J. Jancarik, J. Jones, H. D. Morgan et al., Crystal structure of cyclin-dependent kinase 2, Nature, vol.363, issue.6430, pp.595-602, 1993.
DOI : 10.1038/363595a0

D. Falco, G. Giordano, and A. , CDK9 (PITALRE): A multifunctional cdc2-related kinase, Journal of Cellular Physiology, vol.177, issue.4, pp.501-506, 1998.
DOI : 10.1002/(SICI)1097-4652(199812)177:4<501::AID-JCP1>3.0.CO;2-4

D. Marco, A. De-simone, C. Raglione, M. Testa, A. Trinca et al., Importance of the type of soil for the induction of micronuclei and the growth of primary roots of Vicia faba treated with the herbicides atrazine, glyphosate and maleic hydrazide, Mutation Research/Genetic Toxicology, vol.279, issue.1, pp.9-13, 1992.
DOI : 10.1016/0165-1218(92)90260-7

D. Nadai, C. Cailliau, K. Epel, D. Ciapa, and B. , Detection of phospholipase Cgamma in sea urchin eggs, Development, Growth and Differentiation, vol.40, issue.5, pp.669-676, 1998.
DOI : 10.1046/j.1440-169X.1998.00391.x

A. J. De-roos, S. H. Zahm, K. P. Cantor, D. D. Weisenburger, F. F. Holmes et al., Integrative assessment of multiple pesticides as risk factors for non-Hodgkin's lymphoma among men, Occupational and Environmental Medicine, vol.60, issue.9, p.11, 2003.
DOI : 10.1136/oem.60.9.e11

D. Ruiter and H. , Developments in adjuvant use for agrochemicals, Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet, vol.67, pp.19-25, 2002.

D. Smedt, V. Poulhe, R. Cayla, X. Dessauge, F. Karaiskou et al., Thr-161 Phosphorylation of Monomeric Cdc2. REGULATION BY PROTEIN PHOSPHATASE 2C IN XENOPUS OOCYTES, Journal of Biological Chemistry, vol.277, issue.32, pp.28592-28600, 2002.
DOI : 10.1074/jbc.M202742200

C. Delalande, R. Bellé, P. Cormier, and O. Mulner-lorillon, Transient Increase of a Protein Kinase Activity Identified to CK2 during Sea Urchin Development, Biochemical and Biophysical Research Communications, vol.266, issue.2, pp.425-431, 1999.
DOI : 10.1006/bbrc.1999.1842

J. Deman and N. Van-larebeke, Carcinogenesis: Mutations and Mutagens, Tumor Biology, vol.22, issue.3, pp.191-202, 2001.
DOI : 10.1159/000050615

G. Deschomets, Les adjuvants du glyphosate, Phytoma, vol.541, pp.14-16, 2001.

A. Devault, D. Fesquet, J. C. Cavadore, A. M. Garrigues, J. C. Labbe et al., Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2, The Journal of Cell Biology, vol.118, issue.5, pp.1109-1120, 1992.
DOI : 10.1083/jcb.118.5.1109

M. Donzelli and G. F. Draetta, Regulating mammalian checkpoints through Cdc25 inactivation, EMBO Reports, vol.4, issue.7, pp.671-677, 2003.
DOI : 10.1038/sj.embor.embor887

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326326

M. Dorée, Le d??clenchement de la mitose chez les eucaryotes sup??rieurs, m??decine/sciences, vol.19, issue.3, pp.299-307, 2003.
DOI : 10.1051/medsci/2003193299

F. Dubé, Effect of reduced protein synthesis on the cell cycle in sea urchin embryos, Journal of Cellular Physiology, vol.82, issue.3, pp.545-552, 1988.
DOI : 10.1002/jcp.1041370321

B. Ducommun, G. Draetta, P. Young, and D. Beach, Fission yeast CDC25 is a cell-cycle regulated protein, Biochemical and Biophysical Research Communications, vol.167, issue.1, pp.301-309, 1990.
DOI : 10.1016/0006-291X(90)91765-K

W. G. Dunphy, L. Brizuela, D. Beach, and J. Newport, The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis, Cell, vol.54, issue.3, pp.423-431, 1988.
DOI : 10.1016/0092-8674(88)90205-X

W. G. Dunphy and A. Kumagai, The cdc25 protein contains an intrinsic phosphatase activity, Cell, vol.67, issue.1, pp.189-196, 1991.
DOI : 10.1016/0092-8674(91)90582-J

C. Eason and K. O-'halloran, Biomarkers in toxicology versus ecological risk assessment, Toxicology, vol.181, issue.182, pp.517-521, 2002.
DOI : 10.1016/S0300-483X(02)00472-9

M. Eddleston and M. R. Phillips, Self poisoning with pesticides, BMJ, vol.328, issue.7430, pp.42-44, 2004.
DOI : 10.1136/bmj.328.7430.42

S. V. Ekholm and S. I. Reed, Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle, Current Opinion in Cell Biology, vol.12, issue.6, pp.676-684, 2000.
DOI : 10.1016/S0955-0674(00)00151-4

R. K. Elespuru and D. Beach, Future approaches to genetic toxicology risk assessment Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins, Mutat Res Galaktionov, Cell, vol.67, pp.1181-1194, 1991.

K. Galaktionov, A. K. Lee, J. Eckstein, G. Draetta, J. Meckler et al., CDC25 phosphatases as potential human oncogenes, Science, vol.269, issue.5230, pp.1575-1577, 1995.
DOI : 10.1126/science.7667636

J. Gautier, C. Norbury, M. Lohka, P. Nurse, and J. Maller, Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+, Cell, vol.54, issue.3, pp.433-439, 1988.
DOI : 10.1016/0092-8674(88)90206-1

J. Gautier, M. J. Solomon, R. N. Booher, J. F. Bazan, and M. W. Kirschner, cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2, Cell, vol.67, issue.1, pp.197-211, 1991.
DOI : 10.1016/0092-8674(91)90583-K

F. Girard, U. Strausfeld, A. Fernandez, and N. J. Lamb, Cyclin a is required for the onset of DNA replication in mammalian fibroblasts, Cell, vol.67, issue.6, pp.1169-1179, 1991.
DOI : 10.1016/0092-8674(91)90293-8

G. Giudice, Developmental biology of the sea urchin embryo. Editions Academic press, 1973.

A. F. Giusti, F. J. O-'neill, K. Yamasu, K. R. Foltz, and L. A. Jaffe, Function of a sea urchin egg Src family kinasein initiating Ca2+ release at fertilization, Developmental Biology, vol.256, issue.2, pp.367-378, 2003.
DOI : 10.1016/S0012-1606(03)00043-5

I. H. Goldberg, M. Rabinowitz, and E. Reich, BASIS OF ACTINOMYCIN ACTION, I. DNA BINDING AND INHIBITION OF RNA-POLYMERASE SYNTHETIC REACTIONS BY ACTINOMYCIN, Proceedings of the National Academy of Sciences, vol.48, issue.12, pp.2094-2101, 1962.
DOI : 10.1073/pnas.48.12.2094

K. L. Gould, S. Moreno, D. J. Owen, S. Sazer, and P. Nurse, Phosphorylation at Thr167 is required for Schizosaccharomyces pombe P34cdc2 function, Trends in Cell Biology, vol.2, issue.2, pp.3297-3309, 1991.
DOI : 10.1016/0962-8924(92)90158-J

K. L. Gould, S. Moreno, N. K. Tonks, and P. Nurse, Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase, Science, vol.250, issue.4987, pp.1573-1576, 1990.
DOI : 10.1126/science.1703321

K. L. Gould and P. Nurse, Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis, Nature, vol.342, issue.6245, pp.39-45, 1989.
DOI : 10.1038/342039a0

A. S. Goustin and F. H. Wilt, Protein synthesis, polyribosomes, and peptide elongation in early development of Strongylocentrotus purpuratus, Developmental Biology, vol.82, issue.1, pp.32-40, 1981.
DOI : 10.1016/0012-1606(81)90426-7

J. L. Grainger, V. Brunn, A. Winkler, and M. M. , Transient synthesis of a specific set of proteins during the rapid cleavage phase of sea urchin development, Developmental Biology, vol.114, issue.2, pp.403-415, 1986.
DOI : 10.1016/0012-1606(86)90205-8

J. L. Grainger and M. M. Winkler, Fertilization triggers unmasking of maternal mRNAs in sea urchin eggs., Molecular and Cellular Biology, vol.7, issue.11, pp.3947-3954, 1987.
DOI : 10.1128/MCB.7.11.3947

J. L. Grainger, M. M. Winkler, S. S. Shen, and R. A. Steinhardt, Intracellular pH controls protein synthesis rate in the sea urchin egg and early embryo, Developmental Biology, vol.68, issue.2, pp.396-406, 1979.
DOI : 10.1016/0012-1606(79)90213-6

P. R. Gross and G. H. Cousineau, Effects of actinomycin D on macromolecule synthesis and early development in sea urchin eggs, Biochemical and Biophysical Research Communications, vol.10, issue.4, pp.321-326, 1963.
DOI : 10.1016/0006-291X(63)90532-1

P. R. Gross and G. H. Cousineau, Macromolecule synthesis and the influence of actinomycin on early development, Experimental Cell Research, vol.33, issue.3, pp.368-395, 1964.
DOI : 10.1016/0014-4827(64)90002-3

P. R. Gross and B. J. Fry, Continuity of Protein Synthesis Through Cleavage Metaphase, Science, vol.153, issue.3737, pp.749-751, 1966.
DOI : 10.1126/science.153.3737.749

Y. Gu, J. Rosenblatt, and D. O. Morgan, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15, Embo J, vol.11, pp.3995-4005, 1992.

L. Hardell and M. Eriksson, A case-control study of non-Hodgkin lymphoma and exposure to pesticides, Cancer, vol.47, issue.6, pp.1353-1360, 1999.
DOI : 10.1002/(SICI)1097-0142(19990315)85:6<1353::AID-CNCR19>3.0.CO;2-1

L. Hardell, M. Eriksson, and M. Nordstrom, Exposure to Pesticides as Risk Factor for Non-Hodgkin's Lymphoma and Hairy Cell Leukemia: Pooled Analysis of Two Swedish Case-control Studies, Leukemia & Lymphoma, vol.43, issue.5, pp.1043-1049, 2002.
DOI : 10.1080/10428190290021560

J. W. Harper and P. D. Adams, Cyclin-Dependent Kinases, Chemical Reviews, vol.101, issue.8, pp.2511-2526, 2001.
DOI : 10.1021/cr0001030

URL : http://wellcomeimages.org/ixbin/hixclient.exe?MIROPAC=B0002861

L. H. Hartwell and T. A. Weinert, Checkpoints: controls that ensure the order of cell cycle events, Science, vol.246, issue.4930, pp.629-634, 1989.
DOI : 10.1126/science.2683079

J. W. Heinecke and B. M. Shapiro, Protein kinase C activates the respiratory burst of fertilization, but not cortical granule exocytosis, in ionophore-stimulated sea urchin eggs, Developmental Biology, vol.142, issue.1, pp.216-223, 1990.
DOI : 10.1016/0012-1606(90)90165-F

H. Hermeking, The 14-3-3 cancer connection, Nature Reviews Cancer, vol.3, issue.12, pp.931-943, 2003.
DOI : 10.1038/nrc1230

M. B. Hille, J. N. Dholakia, A. Wahba, E. Fanning, L. Stimler et al., In-vivo and in-vitro evidence supporting co-regulation of translation in sea-urchin eggs by polypeptide initiation factors, pH optimization, and mRNAs, J Reprod Fert, vol.42, pp.235-248, 1990.

E. H. Hinchcliffe, E. A. Thompson, F. J. Miller, J. Yang, and G. Sluder, Nucleocytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote, J Cell Sci, vol.112, pp.1139-1148, 1999.

M. L. Hixon and A. Gualberto, The control of mitosis, Frontiers in Bioscience, vol.5, issue.3, pp.50-57, 2000.
DOI : 10.2741/A495

R. Honda, Y. Ohba, A. Nagata, H. Okayama, and H. Yasuda, Dephosphorylation of human, 1993.

R. Honda, Y. Ohba, and H. Yasuda, The cell cycle regulator, human p50weel, is a tyrosine kinase and not a serine/tyrosine kinase, Biochemical and Biophysical Research Communications, vol.186, issue.3, pp.1333-1338, 1992.
DOI : 10.1016/S0006-291X(05)81552-9

S. Hörstadius, Experimental embryology of Echinoderms, 1973.

T. Hultin, The effect of puromycin on protein metabolism and cell division in fertilized sea urchin eggs, Experientia, vol.2, issue.9, pp.410-411, 1961.
DOI : 10.1007/BF02157974

A. Iavarone and J. Massague, Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-?? in cells lacking the CDK inhibitor p15, Nature, vol.387, issue.6631, pp.417-422, 1997.
DOI : 10.1038/387417a0

S. Ikegami, S. Amemiya, M. Oguro, H. Nagano, and Y. Mano, Inhibition by aphidicolin of cell cycle progression and DNA replication in sea urchin embryos, Journal of Cellular Physiology, vol.101, issue.3, pp.439-444, 1979.
DOI : 10.1002/jcp.1041000307

G. Iliakis, Y. Wang, J. Guan, and H. Wang, DNA damage checkpoint control in cells exposed to ionizing radiation, Oncogene, vol.22, issue.37, pp.5834-5847, 2003.
DOI : 10.1038/sj.onc.1206682

T. Izumi, D. H. Walker, and J. L. Maller, Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity., Molecular Biology of the Cell, vol.3, issue.8, pp.927-939, 1992.
DOI : 10.1091/mbc.3.8.927

K. Jaga and C. Dharmani, Sources of exposure to and public health implications of organophosphate pesticides, Revista Panamericana de Salud P??blica, vol.14, issue.3, pp.171-185, 2003.
DOI : 10.1590/S1020-49892003000800004

V. Janssens and J. Goris, Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling, Biochemical Journal, vol.353, issue.3, pp.417-439, 2001.
DOI : 10.1042/bj3530417

P. D. Jeffrey, A. A. Russo, K. Polyak, E. Gibbs, J. Hurwitz et al., Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex, Nature, vol.376, issue.6538, pp.313-320, 1995.
DOI : 10.1038/376313a0

C. Jessus and D. Beach, Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B, Cell, vol.68, issue.2, pp.323-332, 1992.
DOI : 10.1016/0092-8674(92)90473-P

C. Jessus and R. Ozon, Function and regulation of cdc25 protein phosphate through mitosis and meiosis, Prog Cell Cycle Res, vol.1, pp.215-228, 1995.

S. Jinno, K. Suto, A. Nagata, M. Igarashi, Y. Kanaoka et al., Cdc25A is a novel phosphatase functioning early in the cell cycle, Embo J, vol.13, pp.1549-1556, 1994.

W. Jiraungkoorskul, E. S. Upatham, M. Kruatrachue, S. Sahaphong, S. Vichasri-grams et al., Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus), Environmental Toxicology, vol.21, issue.4, pp.260-267, 2003.
DOI : 10.1002/tox.10123

J. D. Johnson and D. Epel, Intracellular pH and activation of sea urchin eggs after fertilisation, Nature, vol.61, issue.5570, pp.661-664, 1976.
DOI : 10.1038/262661a0

A. Karaiskou, X. Cayla, O. Haccard, C. Jessus, and R. Ozon, MPF Amplification inXenopusOocyte Extracts Depends on a Two-Step Activation of Cdc25 Phosphatase, Experimental Cell Research, vol.244, issue.2, pp.491-500, 1998.
DOI : 10.1006/excr.1998.4220

A. Karaiskou, C. Jessus, T. Brassac, and R. Ozon, Phosphatase 2A and polo kinase, two antagonistic regulators of cdc25 activation and MPF auto-amplification, J Cell Sci, vol.112, pp.3747-3756, 1999.

M. Kasten and A. Giordano, Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity, Oncogene, vol.20, issue.15, pp.1832-1838, 2001.
DOI : 10.1038/sj.onc.1204295

B. Kaya, A. Creus, A. Yanikoglu, O. Cabre, and R. Marcos, Use of the Drosophila wing spot test in the genotoxicity testing of different herbicides, Environmental and Molecular Mutagenesis, vol.7, issue.1, pp.40-46, 2000.
DOI : 10.1002/1098-2280(2000)36:1<40::AID-EM6>3.0.CO;2-K

K. Keyomarsi and A. B. Pardee, Redundant cyclin overexpression and gene amplification in breast cancer cells., Proceedings of the National Academy of Sciences, vol.90, issue.3, pp.1112-1116, 1993.
DOI : 10.1073/pnas.90.3.1112

S. H. Kim, C. Li, and J. L. Maller, A Maternal Form of the Phosphatase Cdc25A Regulates Early Embryonic Cell Cycles in Xenopus laevis, Developmental Biology, vol.212, issue.2, pp.381-391, 1999.
DOI : 10.1006/dbio.1999.9361

R. W. King, R. J. Deshaies, J. M. Peters, and M. W. Kirschner, How Proteolysis Drives the Cell Cycle, Science, vol.274, issue.5293, pp.1652-1659, 1996.
DOI : 10.1126/science.274.5293.1652

W. H. Kinsey, Tyrosine Kinase Signaling at Fertilization, Biochemical and Biophysical Research Communications, vol.240, issue.3, pp.519-522, 1997.
DOI : 10.1006/bbrc.1997.7586

J. C. Kleinjans, Principles in toxicological risk analysis, Toxicology Letters, vol.140, issue.141, pp.140-141, 2003.
DOI : 10.1016/S0378-4274(03)00027-4

N. Kohzato, Y. Dong, L. Sui, T. Masaki, S. Nagahata et al., Overexpression of cyclin E and cyclin-dependent kinase 2 is correlated with development of hepatocellular carcinomas, Hepatology Research, vol.21, issue.1, pp.27-39, 2001.
DOI : 10.1016/S1386-6346(00)00150-9

W. Krek and E. A. Nigg, Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates, Embo J, vol.10, pp.3331-3341, 1991.

W. Krek and E. A. Nigg, Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites, Embo J, vol.10, pp.305-316, 1991.

W. Krek and E. A. Nigg, Cell cycle regulation of vertebrate p34cdc2 activity: identification of Thr161 as an essential in vivo phosphorylation site, New Biol, vol.4, pp.323-329, 1992.

M. Kubelka, M. Anger, J. Kalous, R. M. Schultz, and J. Motlik, Chromosome condensation in pig oocytes: Lack of a requirement for either cdc2 kinase or MAP kinase activity, Molecular Reproduction and Development, vol.72, issue.3, pp.110-118, 2002.
DOI : 10.1002/mrd.10176

A. Kumagai and W. G. Dunphy, Regulation of the cdc25 protein during the cell cycle in Xenopus extracts, Cell, vol.70, issue.1, pp.139-151, 1992.
DOI : 10.1016/0092-8674(92)90540-S

A. Kumagai and W. G. Dunphy, Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts, Science, vol.273, issue.5280, pp.1377-1380, 1996.
DOI : 10.1126/science.273.5280.1377

A. Kumagai and W. G. Dunphy, Binding of 14-3-3??proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25, Genes & Development, vol.13, issue.9, pp.1067-1072, 1999.
DOI : 10.1101/gad.13.9.1067

A. Kumagai, P. S. Yakowec, and W. G. Dunphy, 14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 in Xenopus Egg Extracts, Molecular Biology of the Cell, vol.9, issue.2, pp.345-354, 1998.
DOI : 10.1091/mbc.9.2.345

J. C. Labbé, J. P. Capony, D. Caput, J. C. Cavadore, J. Derancourt et al., MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B, Embo J, vol.8, pp.3053-3058, 1989.

J. C. Labbé, M. G. Lee, P. Nurse, A. Picard, and M. Doree, Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+, Nature, vol.335, issue.6187, pp.251-254, 1988.
DOI : 10.1038/335251a0

H. L. Lee, K. W. Chen, C. H. Chi, J. J. Huang, and L. M. Tsai, Clinical Presentations and Prognostic Factors of a Glyphosate ??? Surfactant Herbicide Intoxication A Review of 131 Cases, Academic Emergency Medicine, vol.34, issue.8, pp.906-910, 2000.
DOI : 10.1016/S0140-6736(88)91205-6

M. S. Lee, T. Enoch, and H. Piwnica-worms, mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15, J Biol Chem, vol.269, pp.30530-30537, 1994.

M. S. Lee, S. Ogg, M. Xu, L. L. Parker, D. J. Donoghue et al., cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2., Molecular Biology of the Cell, vol.3, issue.1, pp.73-84, 1992.
DOI : 10.1091/mbc.3.1.73

T. Lepage and C. Gache, Purification and characterization of the sea urchin embryo hatching enzyme, J Biol Chem, vol.264, pp.4787-4793, 1989.

T. Lepage and C. Gache, Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo, Embo J, vol.9, pp.3003-3012, 1990.

T. Lepage, C. Sardet, and C. Gache, Spatial expression of the hatching enzyme gene in the sea urchin embryo, Developmental Biology, vol.150, issue.1, pp.23-32, 1992.
DOI : 10.1016/0012-1606(92)90004-Z

M. P. Lesser, V. A. Kruse, and T. M. Barry, Exposure to ultraviolet radiation causes apoptosis in developing sea urchin embryos, Journal of Experimental Biology, vol.206, issue.22, pp.4097-4103, 2003.
DOI : 10.1242/jeb.00621

A. P. Li and T. J. Long, An evaluation of the genotoxic potential of glyphosate*1, Fundamental and Applied Toxicology, vol.10, issue.3, pp.537-546, 1988.
DOI : 10.1016/0272-0590(88)90300-4

M. B. Lioi, M. R. Scarfi, A. Santoro, R. Barbieri, O. Zeni et al., Genotoxicity and oxidative stress induced by pesticide exposure in bovine lymphocyte cultures in vitro, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.403, issue.1-2, pp.13-20, 1998.
DOI : 10.1016/S0027-5107(98)00010-4

M. B. Lioi, M. R. Scarfi, A. Santoro, R. Barbieri, O. Zeni et al., Cytogenetic damage and induction of pro???oxidant state in human lymphocytes exposed in vitro to gliphosate, vinclozolin, atrazine, and DPX???E9636, Environmental and Molecular Mutagenesis, vol.32, issue.1, pp.39-46, 1998.
DOI : 10.1002/(SICI)1098-2280(1998)32:1<39::AID-EM5>3.3.CO;2-G

T. Lorca, J. C. Labbe, A. Devault, D. Fesquet, J. P. Capony et al., Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase, Embo J, vol.11, pp.2381-2390, 1992.

F. C. Lu, A Review of the Acceptable Daily Intakes of Pesticides Assessed by WHO, Regulatory Toxicology and Pharmacology, vol.21, issue.3, pp.352-364, 1995.
DOI : 10.1006/rtph.1995.1049

A. Lueken, U. Juhl-strauss, G. Krieger, and I. Witte, Synergistic DNA damage by oxidative stress (induced by H2O2) and nongenotoxic environmental chemicals in human fibroblasts, Toxicology Letters, vol.147, issue.1, pp.35-43, 2004.
DOI : 10.1016/j.toxlet.2003.10.020

K. Lundgren, N. Walworth, R. Booher, M. Dembski, M. Kirschner et al., mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2, Cell, vol.64, issue.6, pp.1111-1122, 1991.
DOI : 10.1016/0092-8674(91)90266-2

T. P. Mäkelä, J. P. Tassan, E. A. Nigg, S. Frutiger, G. J. Hughes et al., A cyclin associated with the CDK-activating kinase MO15, Nature, vol.371, issue.6494, pp.254-257, 1994.
DOI : 10.1038/371254a0

T. Malarkey, Human health concerns with GM crops, Mutation Research/Reviews in Mutation Research, vol.544, issue.2-3, pp.217-221, 2003.
DOI : 10.1016/j.mrrev.2003.06.001

J. Malik, G. Barry, and G. Kishore, The herbicide glyphosate, Biofactors, vol.2, pp.17-25, 1989.

J. L. Maller, Maturation-promoting factor in the early days, Trends in Biochemical Sciences, vol.20, issue.12, pp.524-528, 1995.
DOI : 10.1016/S0968-0004(00)89122-7

R. M. Mann and J. R. Bidwell, The Toxicity of Glyphosate and Several Glyphosate Formulations to Four Species of Southwestern Australian Frogs, Archives of Environmental Contamination and Toxicology, vol.36, issue.2, pp.193-199, 1999.
DOI : 10.1007/s002449900460

J. Marc, O. Mulner-lorillon, and R. Bellé, Glyphosate-based pesticides affect cell cycle regulation, Biology of the Cell, vol.96, issue.3, pp.245-249, 2004.
DOI : 10.1016/j.biolcel.2003.11.010

J. Marc, O. Mulner-lorillon, G. Durand, and R. Bellé, Embryonic cell cycle for risk assessment of pesticides at the molecular level, Environmental Chemistry Letters, vol.1, issue.1, pp.8-12, 2003.
DOI : 10.1007/s10311-002-0015-2

S. S. Margolis and S. Kornbluth, When the Checkpoints Have Gone: Insights into Cdc25 Functional Activation, Cell Cycle, vol.3, issue.4, pp.425-428, 2004.
DOI : 10.4161/cc.3.4.817

S. S. Margolis, S. Walsh, D. C. Weiser, M. Yoshida, S. Shenolikar et al., PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation, The EMBO Journal, vol.22, issue.21, pp.5734-5745, 2003.
DOI : 10.1093/emboj/cdg545

M. Maroni, C. Colosio, A. Ferioli, and A. Fait, Biological Monitoring of Pesticide Exposure: a review, Introduction. Toxicology, vol.143, pp.1-118, 2000.

M. Maroni, A. Fait, and C. Colosio, Risk assessment and management of occupational exposure to pesticides, Toxicology Letters, vol.107, issue.1-3, pp.145-153, 1999.
DOI : 10.1016/S0378-4274(99)00041-7

H. H. Mcduffie, P. Pahwa, J. R. Mclaughlin, J. J. Spinelli, S. Fincham et al., Non-Hodgkin's lymphoma and specific pesticide exposures in men: cross-Canada study of pesticides and health, 2001.

C. H. Mcgowan and P. Russell, Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15, Embo J, vol.12, pp.75-85, 1993.

L. Meijer, L. Azzi, and J. Y. Wang, Cyclin B targets p34cdc2 for tyrosine phosphorylation, Embo J, vol.10, pp.1545-1554, 1991.

L. Meijer and P. Pondaven, Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions, Experimental Cell Research, vol.174, issue.1, pp.116-129, 1988.
DOI : 10.1016/0014-4827(88)90147-4

O. Meyer, Testing and assessment strategies, including alternative and new approaches, Toxicology Letters, vol.140, issue.141, pp.140-141, 2003.
DOI : 10.1016/S0378-4274(02)00492-7

J. B. Millar and P. Russell, The cdc25 M-phase inducer: An unconventional protein phosphatase, Cell, vol.68, issue.3, pp.407-410, 1992.
DOI : 10.1016/0092-8674(92)90177-E

D. G. Mitchell, P. M. Chapman, and T. J. Long, Acute toxicity of Roundup?? and Rodeo?? herbicides to rainbow trout, chinook, and coho salmon, Bulletin of Environmental Contamination and Toxicology, vol.11, issue.6, pp.1028-1035, 1987.
DOI : 10.1007/BF01689594

J. Mitra and G. H. Enders, Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells, Oncogene, vol.23, issue.19, pp.3361-3367, 2004.
DOI : 10.1038/sj.onc.1207446

M. Molinari, Cell cycle checkpoints and their inactivation in human cancer, Cell Proliferation, vol.12, issue.5, pp.261-274, 2000.
DOI : 10.1046/j.1365-2184.2000.00191.x

A. Monnier, J. Morales, P. Cormier, S. Boulben, R. Bellé et al., Protein translation during early cell divisions of sea urchin embryos regulated at the level of polypeptide chain elongation and highly sensitive to natural polyamines, Zygote, vol.9, issue.03, pp.229-236, 2001.
DOI : 10.1017/S0967199401001241

R. T. Moon, K. D. Moe, and M. B. Hille, Polypeptides of nonpolyribosomal messenger ribonucleoprotein complexes of sea urchin eggs, Biochemistry, vol.19, issue.12, pp.2723-2730, 1980.
DOI : 10.1021/bi00553a029

J. C. Moore, J. L. Sumerel, B. J. Schnackenberg, J. A. Nichols, A. Wikramanayake et al., Cyclin D and cdk4 Are Required for Normal Development beyond the Blastula Stage in Sea Urchin Embryos, Molecular and Cellular Biology, vol.22, issue.13, pp.4863-4875, 2002.
DOI : 10.1128/MCB.22.13.4863-4875.2002

J. L. Moreau, F. Marques, A. Barakat, P. Schatt, J. C. Lozano et al., Cdk2 Activity Is Dispensable for the Onset of DNA Replication during the First Mitotic Cycles of the Sea Urchin Early Embryo, Developmental Biology, vol.200, issue.2, pp.182-197, 1998.
DOI : 10.1006/dbio.1998.8961

D. O. Morgan, Principles of CDK regulation, Nature, vol.374, issue.6518, pp.131-134, 1995.
DOI : 10.1038/374131a0

D. O. Morgan, CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors, Annual Review of Cell and Developmental Biology, vol.13, issue.1, pp.261-291, 1997.
DOI : 10.1146/annurev.cellbio.13.1.261

M. Moriya, T. Ohta, K. Watanabe, T. Miyazawa, K. Kato et al., Further mutagenicity studies on pesticides in bacterial reversion assay systems, Mutation Research/Genetic Toxicology, vol.116, issue.3-4, pp.185-216, 1983.
DOI : 10.1016/0165-1218(83)90059-9

H. I. Morrison, K. Wilkins, R. Semenciw, Y. Mao, and D. Wigle, Herbicides and Cancer, JNCI Journal of the National Cancer Institute, vol.84, issue.24, pp.1866-1874, 1992.
DOI : 10.1093/jnci/84.24.1866

N. Motoyama and K. Naka, DNA damage tumor suppressor genes and genomic instability, Current Opinion in Genetics & Development, vol.14, issue.1, pp.11-16, 2004.
DOI : 10.1016/j.gde.2003.12.003

H. Muckter, What is toxicology and how does toxicity occur?, Best Practice & Research Clinical Anaesthesiology, vol.17, issue.1, pp.5-27, 2003.
DOI : 10.1053/bean.2003.0270

P. R. Mueller, T. R. Coleman, A. Kumagai, and W. G. Dunphy, Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15, Science, vol.270, issue.5233, pp.86-90, 1995.
DOI : 10.1126/science.270.5233.86

A. W. Murray, Recycling the Cell Cycle, Cell, vol.116, issue.2, pp.221-234, 2004.
DOI : 10.1016/S0092-8674(03)01080-8

H. Nakajima, F. Toyoshima-morimoto, E. Taniguchi, and E. Nishida, Identification of a Consensus Motif for Plk (Polo-like Kinase) Phosphorylation Reveals Myt1 as a Plk1 Substrate, Journal of Biological Chemistry, vol.278, issue.28, pp.25277-25280, 2003.
DOI : 10.1074/jbc.C300126200

M. Nemer and E. W. Stuebing, WEE1-like CDK tyrosine kinase mRNA level is regulated temporally and spatially in sea urchin embryos, Mechanisms of Development, vol.58, issue.1-2, pp.75-88, 1996.
DOI : 10.1016/S0925-4773(96)00560-6

E. A. Nigg, Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle, BioEssays, vol.220, issue.6, pp.471-480, 1995.
DOI : 10.1002/bies.950170603

E. A. Nigg, Mitotic kinases as regulators of cell division and its checkpoints, Nature Reviews Molecular Cell Biology, vol.2, issue.1, pp.21-32, 2001.
DOI : 10.1038/35048096

D. Nishioka, C. E. Killian, C. T. Chacon, and M. K. Sgagias, Increased uptake of thymidine in the activation of sea urchin eggs. III. Effects of aphidicolin, Journal of Cellular Physiology, vol.1, issue.1, pp.27-33, 1984.
DOI : 10.1002/jcp.1041180107

D. Nishioka, V. Marcell, M. Cunningham, M. Khan, V. Hoff et al., The Use of Early Sea Urchin Embryos in Anticancer Drug Testing, Methods Mol Med, vol.85, pp.265-276, 2003.
DOI : 10.1385/1-59259-380-1:265

C. J. Norbury and B. Zhivotovsky, DNA damage-induced apoptosis, Oncogene, vol.23, issue.16, pp.2797-2808, 2004.
DOI : 10.1038/sj.onc.1207532

P. Nurse, Universal control mechanism regulating onset of M-phase, Nature, vol.344, issue.6266, pp.503-511, 1990.
DOI : 10.1038/344503a0

P. Nurse, Checkpoint Pathways Come of Age, Cell, vol.91, issue.7, pp.865-867, 1997.
DOI : 10.1016/S0092-8674(00)80476-6

P. Nurse, A Long Twentieth Century of the Cell Cycle and Beyond, Cell, vol.100, issue.1, pp.71-78, 2000.
DOI : 10.1016/S0092-8674(00)81684-0

P. Nurse and P. Thuriaux, Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe, Genetics, vol.96, pp.627-637, 1980.

P. M. Nurse, Nobel Lecture. Cyclin dependent kinases and cell cycle control, Bioscience Reports, vol.22, issue.5/6, pp.487-499, 2002.
DOI : 10.1023/A:1022017701871

K. A. Nyberg, R. J. Michelson, C. W. Putnam, and T. A. Weinert, Toward Maintaining the Genome: DNA Damage and Replication Checkpoints, Annual Review of Genetics, vol.36, issue.1, pp.617-656, 2002.
DOI : 10.1146/annurev.genet.36.060402.113540

O. Farrell and P. H. , Triggering the all-or-nothing switch into mitosis, Trends in Cell Biology, vol.11, issue.12, pp.512-519, 2001.
DOI : 10.1016/S0962-8924(01)02142-0

M. Ohtsubo and J. M. Roberts, Cyclin-dependent regulation of G1 in mammalian fibroblasts, Science, vol.259, issue.5103, pp.1908-1912, 1993.
DOI : 10.1126/science.8384376

T. Okano-uchida, E. Okumura, M. Iwashita, H. Yoshida, K. Tachibana et al., Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles, The EMBO Journal, vol.22, issue.20, pp.5633-5642, 2003.
DOI : 10.1093/emboj/cdg535

E. Okumura, T. Fukuhara, H. Yoshida, H. Si, S. Kozutsumi et al., Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition, Nature Cell Biology, vol.4, issue.2, pp.111-116, 2002.
DOI : 10.1038/ncb741

K. Ookata, S. Hisanaga, T. Okano, K. Tachibana, and T. Kishimoto, Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes, Embo J, vol.11, pp.1763-1772, 1992.

G. Pagano, M. Iaccarino, A. De-biase, S. G. Meric, M. Warnau et al., Factors affecting R6 fungicide toxicity on sea urchin fertilization and early development: Roles of exposure routes and mixture components, Human & Experimental Toxicology, vol.40, issue.87, pp.404-411, 2001.
DOI : 10.1191/096032701682692982

M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta, Cyclin A is required at two points in the human cell cycle, Embo J, vol.11, pp.961-971, 1992.

A. Palmer, A. C. Gavin, and A. R. Nebreda, A link between MAP kinase and p34cdc2/cyclin B during oocyte maturation: p90rsk phosphorylates and inactivates the p34cdc2 inhibitory kinase Myt1, The EMBO Journal, vol.17, issue.17, pp.5037-5047, 1998.
DOI : 10.1093/emboj/17.17.5037

E. Parisi, S. Filosa, B. De-petrocellis, and A. Monroy, The pattern of cell division in the early development of the sea urchin, Paracentrotus lividus, Developmental Biology, vol.65, issue.1, pp.38-49, 1978.
DOI : 10.1016/0012-1606(78)90177-X

L. L. Parker, S. Atherton-fessler, and H. Piwnica-worms, p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15., Proceedings of the National Academy of Sciences, vol.89, issue.7, pp.2917-2921, 1992.
DOI : 10.1073/pnas.89.7.2917

L. L. Parker and H. Piwnica-worms, Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase, Science, vol.257, issue.5078, pp.1955-1957, 1992.
DOI : 10.1126/science.1384126

L. L. Parker, S. A. Walter, P. G. Young, and H. Piwnica-worms, Phosphorylation and inactivation of the mitotic inhibitor Weel by the nim1/cdr1 kinase, Nature, vol.363, issue.6431, pp.736-738, 1993.
DOI : 10.1038/363736a0

R. Patel, E. M. Wright, and M. Whitaker, Summary, Zygote, vol.10, issue.02, pp.127-138, 1997.
DOI : 10.1016/0092-8674(91)90582-J

N. P. Pavletich, Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors, Journal of Molecular Biology, vol.287, issue.5, pp.821-828, 1999.
DOI : 10.1006/jmbi.1999.2640

A. K. Pearce and T. C. Humphrey, Integrating stress-response and cell-cycle checkpoint pathways, Trends in Cell Biology, vol.11, issue.10, pp.426-433, 2001.
DOI : 10.1016/S0962-8924(01)02119-5

M. Peluso, A. Munnia, C. Bolognesi, and S. Parodi, 32P-postlabeling detection of DNA adducts in mice treated with the herbicide roundup, Environmental and Molecular Mutagenesis, vol.79, issue.1, pp.55-59, 1998.
DOI : 10.1002/(SICI)1098-2280(1998)31:1<55::AID-EM8>3.0.CO;2-A

D. Pesando, P. Huitorel, V. Dolcini, C. Angelini, P. Guidetti et al., Biological targets of neurotoxic pesticides analysed by alteration of developmental events in the Mediterranean sea urchin, Paracentrotus lividus, Marine Environmental Research, vol.55, issue.1, pp.39-57, 2003.
DOI : 10.1016/S0141-1136(02)00215-5

M. Peter, L. Peuch, C. Labbe, J. C. Meyer, A. N. Donoghue et al., Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1, EMBO reports, vol.75, issue.6, pp.551-556, 2002.
DOI : 10.1093/embo-reports/kvf111

A. Picard, J. C. Labbe, H. Barakat, J. C. Cavadore, and M. Doree, Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase, The Journal of Cell Biology, vol.115, issue.2, pp.337-344, 1991.
DOI : 10.1083/jcb.115.2.337

J. Pines and T. Hunter, Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport, Trends in Cell Biology, vol.2, issue.1, pp.1-17, 1991.
DOI : 10.1016/0962-8924(92)90129-B

Y. Pommier and K. W. Kohn, Cycle cellulaire et points de contr??le en oncologie : nouvelles cibles th??rapeutiques, m??decine/sciences, vol.19, issue.2, pp.173-186, 2003.
DOI : 10.1051/medsci/2003192173

Y. W. Qian, E. Erikson, F. E. Taieb, and J. L. Maller, The Polo-like Kinase Plx1 Is Required for Activation of the Phosphatase Cdc25C and Cyclin B-Cdc2 in Xenopus Oocytes, Molecular Biology of the Cell, vol.12, issue.6, pp.1791-1799, 2001.
DOI : 10.1091/mbc.12.6.1791

J. M. Raleigh and M. J. Connell, The G(2) DNA damage checkpoint targets both Wee1 and Cdc25, J Cell Sci, vol.113, pp.1727-1736, 2000.

J. Rank, A. G. Jensen, B. Skov, L. H. Pedersen, and K. Jensen, Genotoxicity testing of the herbicide Roundup and its active ingredient glyphosate isopropylamine using the mouse bone marrow micronucleus test, Salmonella mutagenicity test, and Allium anaphase-telophase test, Mutation Research/Genetic Toxicology, vol.300, issue.1, pp.29-36, 1993.
DOI : 10.1016/0165-1218(93)90136-2

J. C. Regier and F. C. Kafatos, Absolute rates of protein synthesis in sea urchins with specific activity measurements of radioactive leucine and leucyl-tRNA, Developmental Biology, vol.57, issue.2, pp.270-283, 1977.
DOI : 10.1016/0012-1606(77)90214-7

M. C. Roccheri, G. Barbata, F. Cardinale, C. Tipa, L. Bosco et al., Apoptosis in Sea Urchin Embryos, Biochemical and Biophysical Research Communications, vol.240, issue.2, pp.359-366, 1997.
DOI : 10.1006/bbrc.1997.7540

E. Rojas, L. A. Herrera, L. A. Poirier, and P. Ostrosky-wegman, Are metals dietary carcinogens?, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.443, issue.1-2, pp.157-181, 1999.
DOI : 10.1016/S1383-5742(99)00018-6

P. Russell and P. Nurse, Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog, Cell, vol.49, issue.4, pp.559-567, 1987.
DOI : 10.1016/0092-8674(87)90458-2

A. A. Russo, P. D. Jeffrey, A. K. Patten, J. Massague, and N. P. Pavletich, Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A???Cdk2 complex, Nature, vol.382, issue.6589, pp.325-331, 1996.
DOI : 10.1038/382325a0

K. Sadhu, S. I. Reed, H. Richardson, and P. Russell, Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2., Proceedings of the National Academy of Sciences, vol.87, issue.13, pp.5139-5143, 1990.
DOI : 10.1073/pnas.87.13.5139

Y. Sanchez, C. Wong, R. S. Thoma, R. Richman, Z. Wu et al., Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25, Science, vol.277, issue.5331, pp.1497-1501, 1997.
DOI : 10.1126/science.277.5331.1497

K. Sato, T. Iwasaki, S. Hirahara, Y. Nishihira, and Y. Fukami, Molecular dissection of egg fertilization signaling with the aid of tyrosine kinase-specific inhibitor and activator strategies, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1697, issue.1-2, pp.103-121, 2004.
DOI : 10.1016/j.bbapap.2003.11.017

J. A. Servizi, R. W. Gordon, and D. W. Martens, Acute toxicity of Garlon 4 and Roundup herbicides to Salmon,Daphnia, and trout, Bulletin of Environmental Contamination and Toxicology, vol.4, issue.1, pp.15-22, 1987.
DOI : 10.1007/BF01691783

L. E. Sever, T. E. Arbuckle, and A. Sweeney, Reproductive and developmental effects of occupational pesticide exposure: the epidemiologic evidence, Occup Med, vol.12, pp.305-325, 1997.

C. J. Sherr and J. M. Roberts, CDK inhibitors: positive and negative regulators of G1-phase progression, Genes & Development, vol.13, issue.12, pp.1501-1512, 1999.
DOI : 10.1101/gad.13.12.1501

J. Shi, Y. Feng, A. C. Goulet, R. R. Vaillancourt, N. A. Sachs et al., The p34cdc2-related Cyclin-dependent kinase 11 Interacts with the p47 Subunit of Eukaryotic Initiation Factor 3 during Apoptosis, Journal of Biological Chemistry, vol.278, issue.7, pp.5062-5071, 2003.
DOI : 10.1074/jbc.M206427200

G. Sluder, F. J. Miller, E. A. Thompson, and D. E. Wolf, Feedback control of the metaphase-anaphase transition in sea urchin zygotes: role of maloriented chromosomes, The Journal of Cell Biology, vol.126, issue.1, pp.189-198, 1994.
DOI : 10.1083/jcb.126.1.189

G. Sluder, E. A. Thompson, F. J. Miller, J. Hayes, and C. L. Rieder, The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry, J Cell Sci, vol.110, pp.421-429, 1997.

G. Sluder, E. A. Thompson, C. L. Rieder, and F. J. Miller, Nuclear envelope breakdown is under nuclear not cytoplasmic control in sea urchin zygotes, The Journal of Cell Biology, vol.129, issue.6, pp.1447-1458, 1995.
DOI : 10.1083/jcb.129.6.1447

E. A. Smith and F. W. Oehme, The biological activity of glyphosate to plants and animals: a literature review, Vet Hum Toxicol, vol.34, pp.531-543, 1992.

G. R. Smith, Effects of Acute Exposure to a Commercial Formulation of Glyphosate on the Tadpoles of Two Species of Anurans, Bulletin of Environmental Contamination and Toxicology, vol.67, issue.4, pp.483-488, 2001.
DOI : 10.1007/s001280149

V. A. Smits, R. Klompmaker, T. Vallenius, G. Rijksen, T. P. Makela et al., p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint, Journal of Biological Chemistry, vol.275, issue.39, pp.30638-30643, 2000.
DOI : 10.1074/jbc.M005437200

K. R. Solomon and D. G. Thompson, Ecological Risk Assessment for Aquatic Organisms from Over-Water Uses of Glyphosate, Journal of Toxicology and Environmental Health, Part B, vol.15, issue.3, pp.289-324, 2003.
DOI : 10.1002/etc.5620150218

M. J. Solomon, M. Glotzer, T. H. Lee, M. Philippe, and M. W. Kirschner, Cyclin activation of p34cdc2, Cell, vol.63, issue.5, pp.1013-1024, 1990.
DOI : 10.1016/0092-8674(90)90504-8

M. J. Solomon, J. W. Harper, and J. Shuttleworth, CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15, Trends in Genetics, vol.9, issue.10, pp.3133-3142, 1993.
DOI : 10.1016/0168-9525(93)90032-D

M. J. Solomon, T. Lee, and M. W. Kirschner, Role of phosphorylation in p34cdc2 activation: identification of an activating kinase., Molecular Biology of the Cell, vol.3, issue.1, pp.13-27, 1992.
DOI : 10.1091/mbc.3.1.13

Z. A. Stewart, M. D. Westfall, and J. A. Pietenpol, Cell-cycle dysregulation and anticancer therapy, Trends in Pharmacological Sciences, vol.24, issue.3, pp.139-145, 2003.
DOI : 10.1016/S0165-6147(03)00026-9

U. Strausfeld, A. Fernandez, J. P. Capony, F. Girard, N. Lautredou et al., Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis, J Biol Chem, vol.269, pp.5989-6000, 1994.

U. Strausfeld, A. Fernandez, J. P. Capony, F. Girard, N. Lautredou et al., Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis, J Biol Chem, vol.269, pp.5989-6000, 1994.

J. L. Sumerel, J. C. Moore, B. J. Schnackenberg, J. A. Nichols, J. C. Canman et al., Cyclin E and Its Associated cdk Activity Do Not Cycle during Early Embryogenesis of the Sea Urchin, Developmental Biology, vol.234, issue.2, pp.425-440, 2001.
DOI : 10.1006/dbio.2001.0260

J. Szarek, A. Siwicki, A. Andrzejewska, E. Terech-majewska, and T. Banaszkiewicz, Effects of the herbicide Roundup??? on the ultrastructural pattern of hepatocytes in carp (Cyprinus carpio), Marine Environmental Research, vol.50, issue.1-5, pp.263-266, 2000.
DOI : 10.1016/S0141-1136(00)00088-X

J. L. Tadeo, C. Sanchez-brunete, R. A. Perez, and M. D. Fernandez, Analysis of herbicide residues in cereals, fruits and vegetables, Journal of Chromatography A, vol.882, issue.1-2, pp.175-191, 2000.
DOI : 10.1016/S0021-9673(00)00103-5

T. Tanaka, . Veeranna, T. Ohshima, P. Rajan, N. D. Amin et al., Neuronal cyclin-dependent kinase 5 activity is critical for survival, J Neurosci, vol.21, pp.550-558, 2001.

Z. Tang, T. R. Coleman, and W. G. Dunphy, Two distinct mechanisms for negative regulation of the Wee1 protein kinase, Embo J, vol.12, pp.3427-3436, 1993.

J. P. Tassan, M. Jaquenoud, A. M. Fry, S. Frutiger, G. J. Hughes et al., In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein, Embo J, vol.14, pp.5608-5617, 1995.

I. Tron, O. Piquet, and S. Cohuet, Effets chroniques des pesticides sur la santé : état actuel des connaissances, 2001.

J. Tsihlias, L. Kapusta, and J. Slingerland, THE PROGNOSTIC SIGNIFICANCE OF ALTERED CYCLIN-DEPENDENT KINASE INHIBITORS IN HUMAN CANCER, Annual Review of Medicine, vol.50, issue.1, pp.401-423, 1999.
DOI : 10.1146/annurev.med.50.1.401

M. T. Tsui and L. M. Chu, Aquatic toxicity of glyphosate-based formulations: comparison between different organisms and the effects of environmental factors, Chemosphere, vol.52, issue.7, 2003.
DOI : 10.1016/S0045-6535(03)00306-0

J. D. Tucker and R. J. Preston, Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment, Mutation Research/Reviews in Genetic Toxicology, vol.365, issue.1-3, pp.147-159, 1996.
DOI : 10.1016/S0165-1110(96)90018-4

K. Vermeulen, D. R. Van-bockstaele, and Z. N. Berneman, The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer, Cell Proliferation, vol.59, issue.3, pp.131-149, 2003.
DOI : 10.1101/gad.827700

N. V. Vigfusson and E. R. Vyse, The effect of the pesticides, dexon, captan and roundup, on sister-chromatid exchanges in human lymphocytes in vitro, Mutation Research/Genetic Toxicology, vol.79, issue.1, pp.53-57, 1980.
DOI : 10.1016/0165-1218(80)90147-0

S. Vollenhofer, K. Burg, J. Schmidt, and H. Kroath, Genetically Modified Organisms in FoodScreening and Specific Detection by Polymerase Chain Reaction, Journal of Agricultural and Food Chemistry, vol.47, issue.12, pp.5038-5043, 1999.
DOI : 10.1021/jf990353l

E. Voronina, W. F. Marzluff, and G. M. Wessel, Cyclin B synthesis is required for sea urchin oocyte maturation, Developmental Biology, vol.256, issue.2, pp.258-275, 2003.
DOI : 10.1016/S0012-1606(02)00134-3

E. Voronina and G. M. Wessel, Apoptosis in sea urchin oocytes, eggs, and early embryos, Molecular Reproduction and Development, vol.69, issue.4, pp.553-561, 2001.
DOI : 10.1002/mrd.1120

M. P. Waalkes, D. A. Fox, J. C. States, S. R. Patierno, M. J. Mccabe et al., Metals and Disorders of Cell Accumulation: Modulation of Apoptosis and Cell Proliferation, Toxicological Sciences, vol.56, issue.2, 2000.
DOI : 10.1093/toxsci/56.2.255

E. B. Wagenaar, The timing of synthesis of proteins required for mitosis in the cell cycle of the sea urchin embryo*1, Experimental Cell Research, vol.144, issue.2, pp.393-403, 1983.
DOI : 10.1016/0014-4827(83)90419-6

L. P. Walsh, C. Mccormick, C. Martin, and D. M. Stocco, Roundup Inhibits Steroidogenesis by Disrupting Steroidogenic Acute Regulatory (StAR) Protein Expression, Environmental Health Perspectives, vol.108, issue.8, pp.769-776, 2000.
DOI : 10.1289/ehp.00108769

N. C. Walworth, Cell-cycle checkpoint kinases: checking in on the cell cycle, Current Opinion in Cell Biology, vol.12, issue.6, pp.697-704, 2000.
DOI : 10.1016/S0955-0674(00)00154-X

R. C. Wester, J. Melendres, R. Sarason, J. Mcmaster, and H. I. Maibach, Glyphosate skin binding, absorption, residual tissue distribution, and skin decontamination, 1991.

A. G. Wildeman and R. N. Nazar, SIGNIFICANCE OF PLANT METABOLISM IN THE MUTAGENICITY AND TOXICITY OF PESTICIDES, Canadian Journal of Genetics and Cytology, vol.24, issue.4, pp.437-449, 1982.
DOI : 10.1139/g82-046

G. M. Williams, R. Kroes, and I. C. Munro, Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans, Regulatory Toxicology and Pharmacology, vol.31, issue.2, pp.117-165, 2000.
DOI : 10.1006/rtph.1999.1371

M. M. Winkler, R. A. Steinhardt, J. L. Grainger, and L. Minning, Dual ionic controls for the activation of protein synthesis at fertilization, Nature, vol.65, issue.5782, pp.558-60, 1980.
DOI : 10.1038/287558a0

B. A. Wolfe and K. L. Gould, Inactivating Cdc25, Mitotic Style, Cell Cycle, vol.3, issue.5, pp.601-603, 2004.
DOI : 10.4161/cc.3.5.891

L. Wu and P. Russell, Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase, Nature, vol.363, issue.6431, pp.738-741, 1993.
DOI : 10.1038/363738a0

C. H. Yam, T. K. Fung, and R. Y. Poon, Cyclin A in cell cycle control and cancer, Cellular and Molecular Life Sciences (CMLS), vol.59, issue.8, pp.1317-1326, 2002.
DOI : 10.1007/s00018-002-8510-y

K. Yamada, Dependence of timing of mitotic events on the rate of protein synthesis and DNA replication in sea urchin early cleavages, Cell Proliferation, vol.104, issue.5-6, pp.203-215, 1998.
DOI : 10.2307/1542817

H. Zhang and J. V. Ruderman, Differential replication capacities of G1 and S-phase extracts from sea urchin eggs, J Cell Sci, vol.104, pp.565-572, 1993.

B. B. Zhou and S. J. Elledge, The DNA damage response: putting checkpoints in perspective, Nature, vol.408, pp.433-439, 2000.