M. Prentki and C. J. Nolan, Islet ?? cell failure in type 2 diabetes, Journal of Clinical Investigation, vol.116, issue.7, p.1802, 2006.
DOI : 10.1172/JCI29103DS1

T. Yamada, Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: Neuronal involvement in food-intake regulation, Cell Metabolism, vol.3, issue.3, p.223, 2006.
DOI : 10.1016/j.cmet.2006.02.001

K. Uno, Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity, Science, vol.312, issue.5780, p.1656, 2006.
DOI : 10.1126/science.1126010

T. K. Lam, G. J. Schwartz, and L. Rossetti, Hypothalamic sensing of fatty acids, Nature Neuroscience, vol.267, issue.5, p.579, 2005.
DOI : 10.1073/pnas.94.16.8878

H. Katagiri, T. Yamada, and Y. Oka, Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals, Circulation Research, vol.101, issue.1, p.27, 2007.
DOI : 10.1161/CIRCRESAHA.107.151621

J. C. Bruning, A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance, Molecular Cell, vol.2, issue.5, p.559, 1998.
DOI : 10.1016/S1097-2765(00)80155-0

R. K. Gupta, Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4??, Genes & Development, vol.21, issue.7, p.756, 2007.
DOI : 10.1101/gad.1535507

D. Gautam, A critical role for ?? cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo, Cell Metabolism, vol.3, issue.6, p.449, 2006.
DOI : 10.1016/j.cmet.2006.04.009

J. Wang, A mutation in the insulin 2 gene induces diabetes with severe pancreatic ??-cell dysfunction in the Mody mouse, Journal of Clinical Investigation, vol.103, issue.1, p.27, 1999.
DOI : 10.1172/JCI4431

S. Oyadomari, Targeted disruption of the Chop gene delays endoplasmic reticulum stress???mediated diabetes, Journal of Clinical Investigation, vol.109, issue.4, p.525, 2002.
DOI : 10.1172/JCI0214550

H. P. Harding and D. Ron, Endoplasmic Reticulum Stress and the Development of Diabetes: A Review, Diabetes, vol.51, issue.Supplement 3, p.455, 2002.
DOI : 10.2337/diabetes.51.2007.S455

R. J. Kaufman, Orchestrating the unfolded protein response in health and disease, Journal of Clinical Investigation, vol.110, issue.10, p.1389, 2002.
DOI : 10.1172/JCI0216886

H. Ishihara, Disruption of the WFS1 gene in mice causes progressive ??-cell loss and impaired stimulus-secretion coupling in insulin secretion, Human Molecular Genetics, vol.13, issue.11, p.1159, 2004.
DOI : 10.1093/hmg/ddh125

A. M. Shapiro, International Trial of the Edmonton Protocol for Islet Transplantation, New England Journal of Medicine, vol.355, issue.13, p.1318, 2006.
DOI : 10.1056/NEJMoa061267

M. We, Yokoyama for the generous gift of recombinant adenoviruses This work was supported by Grants-in, I.); the 21st Center of References and Notes

A. Zingone and H. O. Enevoldsen, The diversity of harmful algal blooms: a challenge for science and management, Ocean & Coastal Management, vol.43, issue.8-9, p.725, 2000.
DOI : 10.1016/S0964-5691(00)00056-9

T. J. Smayda and C. S. Reynolds, Community Assembly in Marine Phytoplankton: Application of Recent Models to Harmful Dinoflagellate Blooms, Journal of Plankton Research, vol.23, issue.5, p.447, 2001.
DOI : 10.1093/plankt/23.5.447

T. J. Smayda and C. S. Reynolds, Strategies of marine dinoflagellate survival and some rules of assembly, Journal of Sea Research, vol.49, issue.2, p.95, 2003.
DOI : 10.1016/S1385-1101(02)00219-8

J. H. Gunderson, S. A. John, W. C. Boman, and D. W. Coats, Multiple Strains of the Parasitic Dinoflagellate Amoebophrya Exist in Chesapeake Bay, The Journal of Eukaryotic Microbiology, vol.21, issue.6, p.469, 2002.
DOI : 10.1093/nar/28.23.4698

B. Díez, C. Pedrós-alió, and R. Massana, Study of Genetic Diversity of Eukaryotic Picoplankton in Different Oceanic Regions by Small-Subunit rRNA Gene Cloning and Sequencing, Applied and Environmental Microbiology, vol.67, issue.7, p.2932, 2001.
DOI : 10.1128/AEM.67.7.2932-2941.2001

L. K. Medlin, K. Metfies, H. Mehl, K. Wiltshire, and K. Valentin, Picoeukaryotic Plankton Diversity at the Helgoland Time Series Site as Assessed by Three Molecular Methods, Microbial Ecology, vol.58, issue.1, p.53, 2006.
DOI : 10.1007/s00248-005-0062-x

L. Guillou, ), Environmental Microbiology, vol.9, issue.12, p.3349, 2008.
DOI : 10.1111/j.1462-2920.2008.01731.x

D. W. Coats and K. R. Bockstahler, Occurrence of the Parasitic Dinoflagellate Amoebophrya ceratii in Chesapeake Bay Populations of Gymnodinium sanguineum, The Journal of Eukaryotic Microbiology, vol.25, issue.6, p.586, 1994.
DOI : 10.1093/plankt/3.2.331

P. Lopez-garcia, H. Philippe, F. Gail, and D. Moreira, Autochthonous eukaryotic diversity in hydrothermal sediment and experimental microcolonizers at the Mid-Atlantic Ridge, Proceedings of the National Academy of Sciences, vol.100, issue.2, p.697, 2003.
DOI : 10.1073/pnas.0235779100

P. S. Salomon, S. Janson, and E. Graneli, Multiple species of the dinophagous dinoflagellate genus Amoebophrya infect the same host species, Environmental Microbiology, vol.22, issue.11, p.1046, 2003.
DOI : 10.1038/nature01346

D. W. Coats and M. G. Park, PARASITISM OF PHOTOSYNTHETIC DINOFLAGELLATES BY THREE STRAINS OF AMOEBOPHRYA (DINOPHYTA): PARASITE SURVIVAL, INFECTIVITY, GENERATION TIME, AND HOST SPECIFICITY1, Journal of Phycology, vol.47, issue.suppl., p.520, 2002.
DOI : 10.1046/j.1529-8817.2002.01200.x

J. F. Maguer, M. Wafar, C. Madec, P. Morin, and E. Erard-le-denn, bloom in the Penz?? Estuary, France, Limnology and Oceanography, vol.49, issue.4, p.1108, 2004.
DOI : 10.4319/lo.2004.49.4.1108

R. M. Keane and M. J. Crawley, Exotic plant invasions and the enemy release hypothesis, Trends in Ecology & Evolution, vol.17, issue.4, p.164, 2002.
DOI : 10.1016/S0169-5347(02)02499-0

A. We, D. Carlier, A. Charruaud, and S. Groisillier, Maury for their earlier contributions to this work

D. Vaulot, P. Dassow, A. Simon, N. Biegala, I. C. Vaulot et al., Worden for critically reading this manuscript; P. Falkowski for his help with References. 1. Not, F Application of fluorescent in situ hybridization coupled with tyramide signal amplification (FISH-TSA) to assess eukaryotic picoplankton composition, Aquatic Microbial Ecology, vol.28, pp.157-166, 2002.

J. H. Gunderson, S. H. Goss, and D. W. Coats, FISH Probes for the Detection of the Parasitic Dinoflagellate Amoebophrya sp. Infecting the Dinoflagellate Akashiwo sanguinea in Chesapeake Bay, The Journal of Eukaryotic Microbiology, vol.37, issue.6, pp.670-675, 2001.
DOI : 10.1046/j.1529-8817.2000.99041.x

J. Maguer, M. Wafar, C. Madec, P. Morin, and E. E. Denn, bloom in the Penz?? Estuary, France, Limnology and Oceanography, vol.49, issue.4, pp.1108-1114, 2004.
DOI : 10.4319/lo.2004.49.4.1108

D. Marie, C. P. Brussaard, R. Thyrhaug, G. Bratbak, and D. Vaulot, Enumeration of marine viruses in culture and natural samples by flow cytometry, Applied and Environmental Microbiology, vol.65, pp.45-52, 1999.

J. J. Doyle and J. L. Doyle, A rapid DNA isolation for small quantities of fresh leaf tissue, Phytochem Bull, vol.19, pp.11-15, 1987.

K. Romari and D. Vaulot, Composition and temporal variability of picoeukaryote communities at a coastal site of the English Channel from 18S rDNA sequences, Limnology and Oceanography, vol.49, issue.3, pp.784-798, 2004.
DOI : 10.4319/lo.2004.49.3.0784

L. Guillou, Widespread occurrence and genetic diversity of marine parasitoids belonging to Syndiniales (Alveolata), Environ Microbiol in press, 2008.

K. Katoh, K. Kuma, H. Toh, and T. Miyata, MAFFT version 5: improvement in accuracy of multiple sequence alignment, Nucleic Acids Research, vol.33, issue.2, pp.511-518, 2007.
DOI : 10.1093/nar/gki198

J. Rozas, J. C. Sánchez-delbarrio, X. Messeguer, R. Rozas, and . Dnasp, DnaSP, DNA polymorphism analyses by the coalescent and other methods, Bioinformatics, vol.19, issue.18, 2003.
DOI : 10.1093/bioinformatics/btg359

P. Morin, Etude des causes de prolifération de microalgues toxiques en mer: Cas d'Alexandrium, 2000.

P. Andersen and H. Sørensen, Population dynamics and trophic coupling in pelagic microorganisms in eutrophic coastal waters, Marine Ecology Progress Series, vol.33, pp.99-109, 1986.
DOI : 10.3354/meps033099

R. Anderson and R. May, Infectious Diseases and Population Cycles of Forest Insects, Science, vol.210, issue.4470, pp.658-661, 1980.
DOI : 10.1126/science.210.4470.658

R. Anderson and R. May, The population dynamics of microparasites and their vertebrate hosts, Phil Trans R Soc Lond, vol.210, pp.658-661, 1981.

D. Anderson, P. Gilbert, and J. Burkholder, Harmful algal blooms and eutrophication: Nutrient sources, composition, and consequences, Estuaries, vol.11, issue.4, pp.704-726, 2002.
DOI : 10.1007/BF02804901

J. Bissinger, D. Montagnes, J. Sharples, and D. Atkinson, Predicting marine phytoplankton maximum growth rates from temperature: Improving on the Eppley curve using quantile regression, Limnology and Oceanography, vol.53, issue.2, pp.487-493, 2008.
DOI : 10.4319/lo.2008.53.2.0487

C. Brussaard, Viral Control of Phytoplankton Populations-a Review1, The Journal of Eukaryotic Microbiology, vol.21, issue.2, pp.125-138, 2004.
DOI : 10.1128/AEM.68.4.1576-1584.2002

J. Burkholder, IMPLICATIONS OF HARMFUL MICROALGAE AND HETEROTROPHIC DINOFLAGELLATES IN MANAGEMENT OF SUSTAINABLE MARINE FISHERIES, Ecological Applications, vol.1, issue.sp1, pp.37-62, 1998.
DOI : 10.1021/cr00021a011

J. Cachon, Contribution à l'étude des péridiniens parasites . Cytologie, cycles évolutifs, Ann Sci Nat Zool, vol.6, pp.1-158, 1964.

J. Cachon and M. Cachon, Parasitic dinoflagellates The biology of dinoflagellates, Blackwell Scientific, pp.571-610, 1987.

A. Calbet, D. Vaqué, F. J. Vila, M. Montserrat, S. Alcaraz et al., Relative grazing impact of microzooplankton and mesozooplankton on a bloom of the toxic dinoflagellate Alexandrium minutum, Marine Ecology Progress Series, vol.259, pp.303-309, 2003.
DOI : 10.3354/meps259303

J. Chattopadhyay and S. Pal, Viral infection on phytoplankton???zooplankton system???a mathematical model, Ecological Modelling, vol.151, issue.1, pp.15-28, 2002.
DOI : 10.1016/S0304-3800(01)00415-X

D. Coats, Parasitic Life Styles of Marine Dinoflagellates, The Journal of Eukaryotic Microbiology, vol.26, issue.1359, pp.402-409, 1999.
DOI : 10.1006/jipa.1995.1043

D. Coats and M. Park, PARASITISM OF PHOTOSYNTHETIC DINOFLAGELLATES BY THREE STRAINS OF AMOEBOPHRYA (DINOPHYTA): PARASITE SURVIVAL, INFECTIVITY, GENERATION TIME, AND HOST SPECIFICITY1, Journal of Phycology, vol.47, issue.suppl., pp.520-528, 2002.
DOI : 10.1046/j.1529-8817.2002.01200.x

D. Coats, K. Bockstahler, G. Berg, and J. Sniezek, Dinoflagellate infections of Favella panamensis from two North American estuaries, Marine Biology, vol.13, issue.1, pp.105-113, 1994.
DOI : 10.1007/BF00350112

D. Coats, E. Adam, C. Gallegos, and S. Hedrick, Parasitism of photosynthetic dinoflagellates in a shallow subestuary of Chesapeake Bay, USA, Aquatic Microbial Ecology, vol.11, pp.1-9, 1996.
DOI : 10.3354/ame011001

P. Donaghay and T. Osborn, Toward a theory of biological-physical control of harmful algal bloom dynamics and impacts, Limnology and Oceanography, vol.42, issue.5part2, pp.1283-1296, 1997.
DOI : 10.4319/lo.1997.42.5_part_2.1283

K. Flynn, K. Jones, and K. Flynn, Comparisons among species ofAlexandrium (Dinophyceae) grown in nitrogen- or phosphorus-limiting batch culture, Marine Biology, vol.103, issue.1, pp.9-18, 1996.
DOI : 10.1007/BF00571372

M. Furnas, Growth rates of summer nanoplankton (<10 ?m) populations in lower Narragansett Bay, Rhode Island, USA, Marine Biology, vol.15, issue.1, pp.105-115, 1982.
DOI : 10.1007/BF00397301

J. Gillooly, Effect of body size and temperature on generation time in zooplankton, Journal of Plankton Research, vol.22, issue.2, pp.241-251, 2000.
DOI : 10.1093/plankt/22.2.241

I. Gismervik, Numerical and functional responses of choreo- and oligotrich planktonic ciliates, Aquatic Microbial Ecology, vol.40, pp.163-173, 2005.
DOI : 10.3354/ame040163

I. Gismervik, Y. Olsen, and O. Vadstein, Micro- and mesozooplankton response to enhanced nutrient input ??? a mesocosm study, Hydrobiologia, vol.484, pp.75-87, 2002.
DOI : 10.1007/978-94-017-3190-4_7

P. Glibert, Interactions of top-down and bottom-up control in planktonic nitrogen cycling, Hydrobiologia, vol.363, pp.1-12, 1997.
DOI : 10.1007/978-94-017-1493-8_1

F. Gómez, The toxic dinoflagellate Gymnodinium catenatum: an invader in the Mediterranean Sea, Acta Bot Croatia, vol.62, pp.65-72, 2003.

S. Griffin, M. Herzfeld, and D. Hamilton, Modelling the impact of zooplankton grazing on phytoplankton biomass during a dinoflagellate bloom in the Swan River Estuary, Western Australia, Ecological Engineering, vol.16, issue.3, pp.373-394, 2001.
DOI : 10.1016/S0925-8574(00)00122-1

G. Hallegraeff, Transport of toxic dinoflagellates via ships' ballast water:bioeconomic risk assessment and efficacy of possible ballast water management strategies, Marine Ecology Progress Series, vol.168, pp.297-309, 1998.
DOI : 10.3354/meps168297

P. Hansen, The red tide dinoflagellate Alexandrmm tamarense: effects on behaviour and growth of a tintinnid ciliate, Marine Ecology Progress Series, vol.53, pp.105-116, 1989.
DOI : 10.3354/meps053105

B. Ibelings, D. Bruin, A. Kagami, M. Rijkeboer, M. Brehm et al., ), Journal of Phycology, vol.6, issue.3, 2004.
DOI : 10.1111/j.1529-8817.2004.03117.x

A. Ismael and K. Amcoats, Alexandrium minutum cysts in Résultats : de la génétique du parasite à la sexualité de l'hôte Methods Cultures Clonal cultures of Scrippsiella trochoidea (Roscoff Culture Collection, RCC1627) were obtained from one vegetative cell obtained after the germination of resting cysts collected in 2005 form the Penzé estuary sediments (North Brittany, France) Cultures were maintained in autoclaved natural seawater from Penzé estuary used as the basis for classical F/2 medium, adjusted to 27 salinity with distilled water, and complement with 5% (v/v) soil extract [Starr and Zeikus, 1993]. Cultures of the parasitoid infecting Scrippsiella trochoidea (RCC1626) were established from the Penzé estuary during summer, All cultures were maintained at 18 ? C and on a light regime of 12L :12D, at 80 µEinstein, 1996.

D. M. Anderson, Turning back the harmful red tide, Nature, vol.388, issue.6642, pp.513-514, 1997.
DOI : 10.1038/41415

R. M. Anderson and R. May, Infectious Diseases and Population Cycles of Forest Insects, Science, vol.210, issue.4470, pp.210-658, 1980.
DOI : 10.1126/science.210.4470.658

R. M. Anderson and R. May, The Population Dynamics of Microparasites and Their Invertebrate Hosts, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.291, issue.1054, pp.291-451, 1054.
DOI : 10.1098/rstb.1981.0005

. Bai, The interplay between host toxins and parasitism by Amoebophrya, Harmful Algae, vol.6, issue.5, pp.670-678, 2007.
DOI : 10.1016/j.hal.2007.01.003

S. L. Baldauf, The Deep Roots of Eukaryotes, Science, vol.300, issue.5626, pp.1703-1706, 2003.
DOI : 10.1126/science.1085544

. Bergh, High abundance of viruses found in aquatic environments, Nature, vol.340, issue.6233, pp.340-467, 1989.
DOI : 10.1038/340467a0

. Binder, . Anderson, B. J. Binder, and D. M. Anderson, PHYSIOLOGICAL AND ENVIRONMENTAL CONTROL OF GERMINATION IN SCRIPPSIELLA TROCHOIDEA (DINOPHYCEAE) RESTING CYSTS1, Journal of Phycology, vol.9, issue.2, pp.99-107, 1987.
DOI : 10.1111/j.1529-8817.1987.tb04431.x

. Bratbak, Viruses and the microbial loop, Microbial Ecology, vol.31, issue.2, pp.209-221, 1994.
DOI : 10.1007/BF00166811

J. Cachon, Contribution à l'étude des péridiniens parasites. Cytologie , cycles évolutifs, Annales des Sciences Naturelles, pp.1-158, 1964.

. Calbet, Relative grazing impact of microzooplankton and mesozooplankton on a bloom of the toxic dinoflagellate Alexandrium minutum, Marine Ecology Progress Series, vol.259, pp.303-309, 2003.
DOI : 10.3354/meps259303

. Canter, . Lund, H. Canter, and J. Lund, Studies on plankton parasites, Transactions of the British Mycological Society, vol.36, issue.1, pp.359-371, 1951.
DOI : 10.1016/S0007-1536(53)80038-0

. Chambouvet, Control of Toxic Marine Dinoflagellate Blooms by Serial Parasitic Killers, Science, vol.322, issue.5905, pp.1254-1257, 2008.
DOI : 10.1126/science.1164387

E. Chatton, Les péridiniens parasites. Morphologie, Reproduction, Ethologie, pp.1-475, 1920.

M. Park, Parasitism of photosynthetic dinoflagellates by three strains of Amoebophrya (Dinophyta) : Parasite survival, infectivity, generation time, and host specificity, Journal of Phycology, vol.38, issue.3, pp.520-528, 2002.

D. W. Coats, Parasitic Life Styles of Marine Dinoflagellates, The Journal of Eukaryotic Microbiology, vol.26, issue.1359, pp.402-409, 1999.
DOI : 10.1006/jipa.1995.1043

. Coats, Parasitism of photosynthetic dinoflagellates in a shallow subestuary of Chesapeake Bay, USA, Aquatic Microbial Ecology, vol.11, pp.1-9, 1996.
DOI : 10.3354/ame011001

D. W. Coats and K. R. Bockstahler, Occurrence of the Parasitic Dinoflagellate Amoebophrya ceratii in Chesapeake Bay Populations of Gymnodinium sanguineum, The Journal of Eukaryotic Microbiology, vol.25, issue.6, pp.41-586, 1994.
DOI : 10.1093/plankt/3.2.331

C. Combes, Interactions durables, 2001.

C. F. Delwiche, Tracing the Thread of Plastid Diversity through the Tapestry of Life, The American Naturalist, vol.154, issue.S4, pp.164-177, 1999.
DOI : 10.1086/303291

D. Desalos and . Díez, alexandrium minutum dans les estuaires nordfinistérien : eaux colorées et toxicité des coquillages en relation avec quelques facteurs naturels Master's thesis Mémoire pour l'obtention du diplôme d'agronomie Study of genetic diversity of eukaryotic picoplankton in different oceanic regions by small-subunit rRNA gene cloning and sequencing, Applied and Environmental Microbiology, issue.7, pp.67-2932, 1999.

. Dicke, M. Bruin-]-dicke, and J. Bruin, Chemical information transfer between plants:, Biochemical Systematics and Ecology, vol.29, issue.10, 2001.
DOI : 10.1016/S0305-1978(01)00045-X

. Dolven, Molecular Diversity of Alveolates Associated with Neritic North Atlantic Radiolarians, Protist, vol.158, issue.1, pp.65-76, 2006.
DOI : 10.1016/j.protis.2006.07.004

D. Doyle, J. J. Doyle, and J. L. Doyle, A rapid DNA isolation procedure for small quantities of fresh leaf tissue, Phytochem. Bull, vol.19, pp.11-15, 1987.

. Edgcomb, Benthic eukaryotic diversity in the Guaymas Basin hydrothermal vent environment, Proceedings of the National Academy of Sciences of the United States of America, pp.99-7658, 2002.
DOI : 10.1073/pnas.062186399

. Emson, R. Mladenov-]-emson, and P. Mladenov, Brittlestar host specificity and apparent host discrimination by the parasitic copepod Ophiopsyllus reductus*, Parasitology, vol.66, issue.01, pp.7-15, 1987.
DOI : 10.1016/0022-0981(83)90016-3

[. Denn, First Report of Parasitism on the Toxic Dinoflagellate Alexandrium minutum Halim, Estuarine, Coastal and Shelf Science, vol.50, issue.1, pp.109-113, 2000.
DOI : 10.1006/ecss.1999.0537

. Fast, Re-examining Alveolate Evolution Using Multiple Protein Molecular Phylogenies, The Journal of Eukaryotic Microbiology, vol.51, issue.1, 2002.
DOI : 10.1038/22099

. Figueroa, MULTIPLE ROUTES OF SEXUALITY IN ALEXANDRIUM TAYLORI (DINOPHYCEAE) IN CULTURE, Journal of Phycology, vol.19, issue.5, pp.1028-1039, 2006.
DOI : 10.1016/0014-4827(86)90202-8

. Mém and . Instfrada, The « Cheshire Cat » escape strategy of the coccolithophore Emiliania huxleyi in response to viral infection, Proceedings of the National Academy of Sciences of the United States of America, pp.105-15944, 2008.

N. Fritz, L. Fritz, and M. Nass, DEVELOPMENT OF THE ENDOPARASITIC DINOFLAGELLATE AMOEBOPHRYA CERATII WITHIN HOST DINOFLAGELLATE SPECIES1, Journal of Phycology, vol.28, issue.3, pp.312-320, 1992.
DOI : 10.1111/j.0022-3646.1992.00312.x

J. Fuhrman, Marine viruses and their biogeochemical and ecological effects, Nature, vol.399, issue.6736, pp.541-548, 1999.
DOI : 10.1038/21119

. Garcés, Relationship between vegetative cells and cyst production during Alexandrium minutum bloom in Arenys de Mar harbour (NW Mediterranean), Journal of Plankton Research, vol.26, issue.6, pp.637-647, 2004.
DOI : 10.1093/plankt/fbh065

. Gardner, Genome sequence of the human malaria parasite Plasmodium falciparum, Nature, vol.241, issue.6906, pp.419-498, 2002.
DOI : 10.1038/nature01099

B. Genovesi-giunti-]-genovesi-giunti, Initiation, maintien et recurrence des efflorescences toxiques d'Alexandrium catenella (dinophyceae) dans une lagune mediterrannenne, 2006.

. Gilbert, The Global, Complex Phenomena of Harmful Algal Blooms, Oceanography, vol.18, issue.2, 2005.
DOI : 10.5670/oceanog.2005.49

. Oceanographygisselson, dinophysis blooms in the deep euphotic zone of the baltic sea : do they grow in the dark ? Harmful algae, pp.130-141, 2002.

. Groisillier, Genetic diversity and habitats of two enigmatic marine alveolate lineages, Aquatic Microbial Ecology, vol.42, issue.3, pp.42-277, 2006.
DOI : 10.3354/ame042277

. Guillou, Widespread occurrence and genetic diversity of marine parasitoids belonging to Syndiniales (Alveolata ), Environ Microbiol, issue.12, pp.10-3349, 2008.

. Gunderson, FISH Probes for the Detection of the Parasitic Dinoflagellate Amoebophrya sp. Infecting the Dinoflagellate Akashiwo sanguinea in Chesapeake Bay, The Journal of Eukaryotic Microbiology, vol.37, issue.6, pp.48-670, 2001.
DOI : 10.1046/j.1529-8817.2000.99041.x

G. M. Hallegraeff, A review of harmful algal blooms and their apparent global increase*, Phycologia, vol.32, issue.2, pp.79-99, 1993.
DOI : 10.2216/i0031-8884-32-2-79.1

. Harada, Species of the Parasitic Genus Duboscquella are Members of the Enigmatic Marine Alveolate Group I, Protist, vol.158, issue.3, 2007.
DOI : 10.1016/j.protis.2007.03.005

K. Harper, J. Harper, and P. Keeling, Nucleus-encoded, Plastid- targeted Glyceraldehyde-3-Phosphate Deshydrogenase (GAPDH) indicates a single origin for chromoalveolate plastids, 2003.

R. Hertwig, Ueber Leptodiscus medusoides, ein neue den Noctilicen verwabdte Flagellate, Jenaische Zeitsch. f. Naturwiss, vol.11, pp.307-323, 1877.

A. Hollande, Etude comparée de la mitose Syndinienne et de celle des péridiniens libres et des hypermastigines, pp.413-451, 1974.

R. Huelsenbeck, J. P. Huelsenbeck, and F. Ronquist, MRBAYES: Bayesian inference of phylogenetic trees, Bioinformatics, vol.17, issue.8, pp.17-754, 2001.
DOI : 10.1093/bioinformatics/17.8.754

G. E. Hutchinson, The Paradox of the Plankton, The American Naturalist, vol.95, issue.882, pp.95-137, 1961.
DOI : 10.1086/282171

. Ibelings, ), Journal of Phycology, vol.6, issue.3, pp.40-437, 2004.
DOI : 10.1111/j.1529-8817.2004.03117.x

A. A. Ismael, Succession of heterotrophic and mixotrophic dinoflagellates as well as autotrophic microplankton in the harbour of Alexandria, Egypt, Journal of Plankton Research, vol.25, issue.2, pp.193-202, 2003.
DOI : 10.1093/plankt/25.2.193

J. Jaenicke, A hypothesis to account for the maintenance of sex within populations, Evol. Theor, vol.3, pp.191-194, 1978.

P. Jiang, S. C. Jiang, and J. H. Paul, Occurrence of lysogenic bacteria in marine microbial communities as determined by prophage induction, Marine Ecology Progress Series, vol.142, pp.1-3, 1996.
DOI : 10.3354/meps142027

D. Coats, Ciliate grazing on the parasite Amoebophrya sp. decreases infection of red-tide dinoflagellate Akashiwo sanguinea, Aquatic Microbial Ecology, vol.28, issue.1, pp.69-78, 2002.

C. Keane, R. M. Keane, and M. J. Crawley, Exotic plant invasions and the enemy release hypothesis, Trends in Ecology & Evolution, vol.17, issue.4, pp.164-170, 2002.
DOI : 10.1016/S0169-5347(02)02499-0

L. Roch, K. G. Sarr, O. Ndir, O. Mboup, S. Batalov et al., A systematic map of genetic variation in Plasmodium falciparum Role of cyst germination in the bloom initiation of Alexandrium tamarense (Dinophyceae), Plos Pathogens Aquat Microb Ecol, vol.2, issue.293, pp.279-286, 2002.

H. Kim, Y. O. Kim, and M. S. Han, Seasonal relationships between cyst germination and vegetative population of Scrippsiella trochoidea (Dinophyceae), Marine Ecology Progress Series, vol.204, pp.111-118, 2000.
DOI : 10.3354/meps204111

A. Kremp, Effects of cyst resuspension on germination and seeding of two bloom-forming dinoflagellates in the Baltic Sea, Marine Ecology Progress Series, vol.216, pp.57-66, 2001.
DOI : 10.3354/meps216057

K. Leander, B. S. Leander, and P. J. Keeling, Morphostasis in alveolate evolution, Trends in Ecology & Evolution, vol.18, issue.8, pp.395-402, 2003.
DOI : 10.1016/S0169-5347(03)00152-6

. Lilly, Paralytic shellfish poisoning toxins in France linked to a human-introduced strain of Alexandrium catenella from the western Pacific: evidence from DNAand toxin analysis, Journal of Plankton Research, vol.24, issue.5, pp.443-452, 2002.
DOI : 10.1093/plankt/24.5.443

. Litaker, LIFE CYCLE OF THE HETEROTROPHIC DINOFLAGELLATE PFIESTERIA PISCICIDA (DINOPHYCEAE)1, Life cycle of the heterotrophic dinoflagellate Pfiesteria piscicida (Dinophyceae), pp.442-463, 2002.
DOI : 10.1111/j.0022-3646.1979.00312.x

I. Loeblich and A. , Dinoflagellate Evolution: Speculation and Evidence*???, The Journal of Protozoology, vol.3, issue.15 (B), pp.13-28, 1976.
DOI : 10.1111/j.1550-7408.1976.tb05241.x

. Lopez-garcia, Autochthonous eukaryotic diversity in hydrothermal sediment and experimental microcolonizers at the Mid-Atlantic Ridge, Proceedings of the National Academy of Sciences of the United States of America, pp.697-702, 2003.
DOI : 10.1073/pnas.0235779100

. Lopez-garcia, Unexpected diversity of small eukaryotes in deep-sea Antartic plankton, Nature, issue.6820, pp.409-603, 2001.

. Maguer, bloom in the Penz?? Estuary, France, Limnology and Oceanography, vol.49, issue.4, pp.1108-1114, 2004.
DOI : 10.4319/lo.2004.49.4.1108

B. Marcus, N. Marcus, and F. Boero, Minireview: The importance of benthic-pelagic coupling and the forgotten role of life cycles in coastal aquatic systems, Limnology and Oceanography, vol.43, issue.5, pp.763-768, 1998.
DOI : 10.4319/lo.1998.43.5.0763

R. Margalef, Alternative approaches in the modeling of populations, Investigacion Pesquera, vol.43, issue.1, pp.337-350, 1979.

E. Margalef, R. Margalef, and M. Estrada, Synoptic distribution of summer microplankton (algae and protozoa) across the principal front in the western Mediterranean, Investigacion Pesquera, vol.51, pp.121-140, 1987.

. Massana, Metagenomic retrieval of a ribosomal DNA repeat array from an uncultured marine alveolate, Environmental Microbiology, vol.50, issue.5, pp.1335-1343, 2008.
DOI : 10.1093/nar/gkg595

. Masselin, Paralytic shellfish poisoning on the French Mediterranean coast in autumn 1998 : Alexandrium tamarense complex (Dinophyceae ) as causative agent, Harmful Algal Blooms, pp.26-29, 2000.

. Meier, Evolution of different life-cycle strategies in oceanic calcareous dinoflagellates, European Journal of Phycology, vol.46, issue.1, pp.81-89, 2007.
DOI : 10.1006/jsbi.1999.4132

. Meinesz, Spread of the introduced tropical green alga Caulerpa taxifolia in northern Mediterranean waters, Journal of Applied Phycology, vol.14, issue.2, pp.141-147, 1995.
DOI : 10.1007/BF00004009

. Monier, Marine mimivirus relatives are probably large algal viruses, Virology Journal, vol.5, issue.1, 2008.
DOI : 10.1186/1743-422X-5-12

. Montagnes, Can microzooplankton and parasite pressure be responsible for the demise of toxic dinoflagellate blooms ?, press), ?, 2008.

. Montresor, Intraspecific diversity in Scrippsiella trochoidea (Dinopbyceae): evidence for cryptic species, 655EM Times Cited :34 Cited References Count, pp.56-7068, 2003.
DOI : 10.2216/i0031-8884-42-1-56.1

. Moon-van-der-staay, Oceanic 18S rDNA sequences from picoplankton reveal unsuspected eukaryotic diversity, Nature, issue.6820, pp.409-607, 2001.

R. Muyzer, G. Muyzer, and N. B. Ramsing, Molecular methods to study the organization of microbial communities . Water science technology, pp.1-9, 1995.

. Nishitani, Role of the parasitic dinoflagellate Amoebophrya ceratii in control of Gonyaulax catenella populations, Toxic Dinoflagellates, pp.225-232, 1985.

. Not, Application of fluorescent in situ hybridization coupled with tyramide signal amplification (FISH-TSA) to assess eukaryotic picoplankton composition, Aquatic Microbial Ecology, vol.28, issue.2, pp.157-166, 2002.
DOI : 10.3354/ame028157

URL : https://hal.archives-ouvertes.fr/hal-00726585

J. Nybakken, Marine biology : An ecological approach, 2001.

. Olli, . Anderson, K. Olli, and D. M. Anderson, HIGH ENCYSTMENT SUCCESS OF THE DINOFLAGELLATE SCRIPPSIELLA CF. LACHRYMOSA IN CULTURE EXPERIMENTS1, 525EJ Times Cited :22 Cited References Count, pp.145-15651, 2002.
DOI : 10.1046/j.1529-8817.2002.01113.x

. Park, Effects of two strains of the parasitic dinoflagellate Amoebophrya on growth, photosynthesis, light absorption, and quantum yield of bloom-forming dinoflagellates, Marine Ecology Progress Series, vol.227, issue.512, pp.281-292, 2002.
DOI : 10.3354/meps227281

. Penna, Alexandrium catenella (Dinophyceae), a toxic ribotype expanding in the NW Mediterranean Sea, Marine Biology, vol.92, issue.1, pp.13-23, 2005.
DOI : 10.1007/s00227-005-0067-5

. Perez, CONTROL OF GERMINATION OF ALEXANDRIUM TAMARENSE (DINOPHYCEAE) CYSTS FROM THE LOWER ST. LAWRENCE ESTUARY (CANADA), Journal of Phycology, vol.34, issue.2, pp.242-24920, 1998.
DOI : 10.1046/j.1529-8817.1998.340242.x

L. A. Pfiester, Sexual Reproduction of Peridinium gatunense (Dinophyceae ), Journal of Phycology, vol.13, issue.1, pp.92-95, 1977.

C. Posada, D. Posada, and K. A. Crandall, MODELTEST: testing the model of DNA substitution, Bioinformatics, vol.14, issue.9, pp.817-818, 1998.
DOI : 10.1093/bioinformatics/14.9.817

K. Poulin, R. Poulin, and D. B. Keeney, Host specificity under molecular and experimental scrutiny, Trends in Parasitology, vol.24, issue.1, pp.24-28, 2007.
DOI : 10.1016/j.pt.2007.10.002

A. Rengefors, K. Rengefors, and D. M. Anderson, ENVIRONMENTAL AND ENDOGENOUS REGULATION OF CYST GERMINATION IN TWO FRESHWATER DINOFLAGELLATES, Journal of Phycology, vol.34, issue.4, pp.568-577, 1998.
DOI : 10.1046/j.1529-8817.1998.340568.x

K. Ris, H. Ris, and D. Kubai, AN UNUSUAL MITOTIC MECHANISM IN THE PARASITIC PROTOZOAN SYNDINIUM SP, The Journal of Cell Biology, vol.60, issue.3, 1974.
DOI : 10.1083/jcb.60.3.702

R. Schmitter, Temporary cysts of Gonyaulax excavata : Effect of temperature and light, Toxic Dinoflagellate Blooms, pp.123-129, 1979.

. Sgrosso, Temperature and daylength regulate encystment in calcareous cyst-forming dinoflagellates, Marine Ecology Progress Series, vol.211, pp.77-87, 2001.
DOI : 10.3354/meps211077

. Skovgaard, . Daugbjerg, A. Skovgaard, and N. Daugbjerg, Identity and Systematic Position of Paradinium poucheti and Other Paradinium-Like Parasites of Marine Copepods Based on Morphology and Nuclear-Encoded SSU rDNA, Protist, vol.159, issue.3, 2008.
DOI : 10.1016/j.protis.2008.02.003

T. J. Smayda, Harmful algal blooms: Their ecophysiology and general relevance to phytoplankton blooms in the sea, Limnology and Oceanography, vol.42, issue.5part2, pp.1137-1153, 1997.
DOI : 10.4319/lo.1997.42.5_part_2.1137

R. Smayda, T. J. Smayda, and C. S. Reynolds, Community Assembly in Marine Phytoplankton: Application of Recent Models to Harmful Dinoflagellate Blooms, Journal of Plankton Research, vol.23, issue.5, pp.447-461, 2001.
DOI : 10.1093/plankt/23.5.447

A. Sournia, Red tide and toxic marine phytoplankton of the world ocean : an inquiry into biodiversity, Harmful Marine Algal Blooms, pp.103-112, 1995.

Z. Starr, R. Starr, and J. Zeikus, UTEX-The culture collection of algae at the University of Texas at Austin, J. Phycol, 1993.

. Stocker, Rapid chemotactic response enables marine bacteria to exploit ephemeral microscale nutrient patches, Proceedings of the National Academy of Sciences, vol.105, issue.11, pp.105-4209, 2008.
DOI : 10.1073/pnas.0709765105

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393791

D. L. Swofford, Paup a Computer-Program for Phylogenetic Infe- BIBLIOGRAPHIE rence Using Maximum Parsimony, Journal of General Physiology, vol.102, issue.6, pp.9-9, 1993.

F. Taylor, General group characteristics ; special features of interest ; short history of dinoflagellate study, The biology of dinoflagellates, 1987.

F. Taylor, Phylum dinoflagellata, Handbook of protoctista, pp.419-437, 1990.

F. J. Taylor, Parasitism of toxin-producing dinoflagellate Gonyaulax catenella by endoparasitic dinoflagellate Amoebophrya ceratii, Journal of the Fisheries Research Board of Canada, issue.10, pp.25-2241, 1968.

T. Thingstad and R. Lignell, Theoretical models for the control of bacterial growth rate, abundance, diversity and carbon demand, Aquatic Microbial Ecology, vol.13, 1997.
DOI : 10.3354/ame013019

. Toth, Marine dinoflagellates show induced life-history shifts to escape parasite infection in response to water-borne signals, Proceedings of the Royal Society of London Series B-Biological Sciences, pp.271-733, 1540.
DOI : 10.1098/rspb.2003.2654

T. Uchida and H. Utermolh, Sexual reproduction of Scrippsiella trochoidea isolated from Muroran Harbor Hokkaido Neue wege in der quantitativen erfassung des planktons (mit besonderes berüksichtigung des planktons), Jap. Sci. Fish Vehr. Int. Ver. Theor. Angew . Limnol, vol.57, issue.5, pp.567-596, 1215.

. Van-valen and L. Van-valen, A new evolutionary law, Evol. Theor, vol.1, pp.1-30, 1973.

. Vila, Is the distribution of the toxic dinoflagellate Alexandrium catenella expanding along the NW Mediterranean coast?, Marine Ecology Progress Series, vol.222, pp.73-83, 2001.
DOI : 10.3354/meps222073

[. Stosch and H. , sp. nov., British Phycological Journal, vol.1917, issue.1, pp.105-134, 1973.
DOI : 10.1080/00071617300650141

J. Waage, How zebra got its stripes. Biting flies as selective agents in the evolution of zebra coloration, Journal of the Entomological Society of South Africa, vol.41, pp.351-358, 1981.

M. Wafar, Nutrients, primary production and dissolved and particulate organic matter in well-mixed temperate coastal water (Bay of morlaix-western English Channel), 1981.

L. Walker, Life histories, dispersal, and survival in marine planktonic dinoflagellates, Marine Plankton Life Cycle Strategies, pp.19-34, 1984.

. Wang, Cyst formation: an important mechanism for the termination of Scrippsiella trochoidea (Dinophyceae) bloom, Journal of Plankton Research, vol.29, issue.2, pp.209-218, 2007.
DOI : 10.1093/plankt/fbm008

R. Weinbauer, M. Weinbauer, and F. Rassoulzadegan, Are viruses driving microbial diversification and diversity?, Environmental Microbiology, vol.68, issue.1, pp.1-11, 2004.
DOI : 10.1046/j.1462-2920.2003.00539.x

. White, Prospects for understanding avirulence gene function, Current Opinion in Plant Biology, vol.3, issue.4, pp.291-298, 2000.
DOI : 10.1016/S1369-5266(00)00082-0

L. Zietaria, M. S. Zietaria, and J. Lumme, Speciation by host switch and adaptative radiation in a fish parasite genus Gyrodactylus (Monogenea, Gyrodactylidae), Evolution, issue.12, pp.56-2245, 2002.

A. Zingone and H. O. Enevoldsen, The diversity of harmful algal blooms: a challenge for science and management, Ocean & Coastal Management, vol.43, issue.8-9, pp.8-9, 2000.
DOI : 10.1016/S0964-5691(00)00056-9